Chemistry, Pharmaceutical.
Overview
| Works: | 262 works in 9 publications in 9 languages | |
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Titles
Thermodynamics of pharmaceutical systems : = an introduction for students of pharmacy /
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Examining the interactive nature of cytochrome P450 3A4 and P-glycoprotein in intestinal drug metabolism.
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Genetic variation in membrane transporters: Implications for drug response.
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Forward and reverse chemical genetic studies of transforming growth factor beta signaling.
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Computational studies of the metal-binding proteins stromelysin-1 and human serum transferrin: Protein modeling and inhibitor design.
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From capillary to microchip electrophoresis: Electrochemical detection of peptides.
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MefA-mediated macrolide resistance in group A streptococci: The search for efflux pump inhibitors from marine natural products.
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Development of ligand assisted asymmetric synthetic methodology and synthetic progress toward AI-77-B.
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From imitation to innovation: The role of patent in China's biotechnology and pharmaceutical industries.
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Study of particle formation using supercritical carbon dioxide as an antisolvent.
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Studies towards the total synthesis of ristocetin A and orienticin C aglycones.
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Studies in organic synthesis: Methodology, vitamin D analogs, and trioxane analogs.
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Physicochemical characterization of camptothecin membrane binding properties and polymeric microsphere formulations.
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A practical synthetic route to structurally diverse tetracycline antibiotics.
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I. The nature of fluorine-mediated intermolecular interactions. II. The fluorophobic effect as a force for molecular recognition and self-assembly.
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Red clover (Trifolium pratense) as a botanical dietary supplement.
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Development of methodologies for asymmetric synthesis and drug discovery.
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Catalytic, enantioselective alkylation of alpha-imino esters: The synthesis of nonnatural alpha-amino acid derivatives.
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Design, synthesis, characterization and drug release kinetics of PAMAM dendrimer based drug formulations.
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Improvement in the bioavailability of poorly water-soluble drugs via pulmonary delivery of nanoparticles.
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Therapeutic antibody formulation: Phase behavior, opalescence, viscosity, physical and chemical stability.
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Targeting biomarkers via CITP-based selective proteome enrichment.
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Surface functionalized mesoporous silica nanoparticles for intracellular drug delivery.
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Discovering the functional diversity of flavonoids derived from Chinese Materia Medica: Drug developments for the prevention of Alzheimer's disease and osteoporosis.
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Molecular genetics and enzymology of secondary metabolite biosynthesis: I. Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II. Enzymology of blasticidin S biosynthesis.
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Development of a system for in-line drug content testing using near infrared reflectance spectroscopy.
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Isolation and characterization of lignan and secoiridoid glucosides from Schrebera alata.
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Quantitative analysis of lycopene and its role in prostate cancer chemoprevention.
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The use of liquid chromatography coupled to tandem mass spectrometry for the quantitation of pharmaceuticals and biological analytes in complex samples.
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Design and development of a rupturable drug delivery system for delivering drug to the distal gastrointestinal tract-colon.
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Sensitivity enhancement in liquid chromatography/atmospheric pressure ionization mass spectrometry using derivatization and mobile phase additives.
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The direct and indirect effects of herbal products on common drug metabolizing enzymes and drug transporters.
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Development of multivalent inhibitors for two protein-protein interactions associated with human leukemia.
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Novel mechanisms in the intestinal absorption of hydrophilic cationic drugs.
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Non-photochemical light-induced nucleation and control of polymorphism through polarization-switching.
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Design, synthesis, and biological evaluation of neo-tanshinlactone and its analogs as potent antibreast cancer agents.
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Molecular authentication of Epimedium species and the anti-osteoporosis effect of Herba Epimedii.
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Poly(amidoamine) (PAMAM) dendrimers as solubility and permeation enhancers.
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Development of a polymeric nanoparticulate delivery system for indocyanine green.
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beta-carotene bioefficacy and prevention of lipid peroxidation by lycopene.
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Development and evaluation of novel liposomal formulations of antibiotics.
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Development of kainic acid analogs as ionotropic glutamate receptor ligands.
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Effects of nonionic surfactants on nystatin aggregation state and toxicity.
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Surface interaction, polarization and molecular weight effects for a whispering gallery mode sensor.
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Characterization of the interaction of the human sodium pump with naturally occurring and synthetic novel inhibitors.
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Transferrin and its oligomer: Intracellular processing and applications as drug carriers.
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In vitro-in vivo evaluation of carbamazepine solid dispersions formulated by supercritical and conventional solvent evaporation method.
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I. Design, synthesis, and biological evaluation of new analogs of bryostatin. II. Investigations into the mode of action of apoptolidin A.
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Development of fluorescent/stable isotope tagging strategies for proteins containing DOPA.
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Progress in the synthesis of sialic acid containing C-glycosides of potentially therapeutic carbohydrate epitopes.
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Preformulation and mechanistic studies on inclusion complexes of selected flavonoids with beta-cyclodextrin and its water-soluble derivatives.
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Synthesis and evaluation of 2,3-dihydroquinazolinones as dual inhibitors of angiogenesis and cancer cell proliferation.
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Abaco Bush medicine: Essential oil composition of aromatic herbal medicines from Abaco Island, Bahamas.
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Implementation and evaluation of a molecular strategy for delivery of nucleic acid based therapeutics.
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Effects of formulation and processing stress on the physical stability of protein solutions.
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Effects of solid-state structure on the tableting properties of pharmaceuticals.
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Prodrug strategies aimed at improving topical delivery of drugs using the N-Alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) promoiety.
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Biological mass spectrometry of sphingolipids in drug discovery and development.
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Novel approaches to assess the efficacy and toxicity of intestinal absorption enhancers.
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3D-QSAR of anti-mitotic, tubulin binding analogs using comparative molecular field analysis (CoMFA).
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Development and validation of in vitro screening procedure for identifying herbals possessing sulfonylurea-like activity.
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Flavonoid analysis of the medicinal plant Scutellaria baicalensis Georgi.
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The rational design of chiral alkyl dihaloboranes and their use as asymmetric Diels-Alder catalysts.
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I. The first highly enantioselective organocatalytic Diels-Alder reaction. II. Development of antibiotics against vancomycin-resistant bacteria. III. Annulation of aromatic imines via directed carbon-hydrogen bond activation .
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Electrochemical stability of insulin and stabilization for iontophoretic transdermal delivery.
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Bioavailability of the tea flavonoids epicatechin and epicatechin gallate: Role of membrane transport and metabolism.
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Development and application of LC/MS and MS/MS methods for the structural characterization of flavonoid glycosides.
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Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria.
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Do you speak genomics? Patenting biotechnology "Translation" inventions and other macromolecules.
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Glycosyltransferases involved in the biosynthesis of glycopeptide antibiotics.
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Advances in computational modeling of enzyme inhibition: Prediction of potency and drug resistance targeting HIV-1 reverse transcriptase.
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A convergent and enantioselective synthetic route to the tetracycline antibiotics.
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I. X-ray crystal structure of the MurG:UDP-GlcNAc cocomplex. II. High throughput screening of Escherichia coli MurG.
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Understanding transglycosylase inhibition: Chlorobiphenyl vancomycin and moenomycin A as targets for synthesis and modification.
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Prospecting for biodiversity: The search for legal and institutional frameworks.
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Biodegradable poly(L-lactide) microparticles for pulmonary drug delivery with targeting to alveolar macrophages: Applications in treating tuberculosis.
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Theoretical aspects of designing new vaccines for breast cancer: Docking studies of peptide/HLA-A2.1 complexes.
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Molecular mobility, physical stability, and transformation kinetics of amorphous and hydrated pharmaceutical solids.
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Ligand binding in human inosine 5'-monophosphate dehydrogenase type I and type II: Crystallographic and kinetic studies.
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Isoflavones and their novel analogues: Effects on EGFR and PTEN/AKT-mediated signaling pathways in glioblastoma multiforme cells.
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In silico prediction of absorption, distribution, metabolism and elimination (ADME).
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Modular synthesis of annonaceous acetogenins and their activity against H-116 human solid colon tumor cells.
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Contributions of the GABA(A) receptor alpha(1) subunit to the structure and dynamics of the neurotransmitter binding pocket.
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Sequence specific DNA minor groove alkylating agents and their biological activity.
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Pharmacophore fingerprint analysis of small molecules and proteins for virtual high throughput screening.
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Targeting topoisomerase II: Two novel approaches toward evaluation of drug-induced catalytic changes to topoisomerase II function.
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New molecular docking and sequence analysis tools for protein kinase studies.
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Design, synthesis, and evaluation of potent androgen receptor targeted prodrugs of doxorubicin.
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Chemical modifications for improvement of the pharmacological properties of therapeutic agents.
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Novel utilization of transition metal organometallic chemistry for the synthesis of natural products.
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Methodology and application of quantitative proton nuclear magnetic resonance in deuterium oxide.
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Photochemistry and phototoxicity of naturally occurring and synthetic chemicals.
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Fluorine and health = molecular imaging, biomedical materials and pharmaceuticals /
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Assessment of the occurrence and potential risks of pharmaceuticals and their metabolites in fish and water using liquid chromatography mass spectrometry.
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Human exposure to indoor organic contaminants, with emphasis on novel brominated flame retardants.
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Affinity chromatographic studies of drug-protein binding in personalized medicine.
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Serum pharmacochemistry of traditional Chinese medicine = technologies, strategies and applications /
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Integration of pharmaceutical discovery and development = case histories /
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In-vitro studies to improve microdialysis recovery of a lipophilic drug: Ketoconazole.
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Improved chemotherapy by hydrophobic ion pairing and localized delivery.
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Drug permeability across the buccal mucosa: Role of ionized species activity and development of a predictive model.
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Transporter-mediated flavonoid-drug interactions: In vitro and in vivo.
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Development of novel mesoporous silicates for bioseparations and biocatalysis.
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The detection, prevalence and properties of aggregate-based small molecule inhibition.
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Biosynthesis and engineering of anticancer antibiotics fredericamycin from Streptomyces griseus and leinamycin from Streptomyces atroolivaceus.
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Improving blood brain barrier permeation of small molecules exhibiting chemotherapeutic and neuroprotective effects.
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A mechanism of resistance and mode of action for drugs against Plasmodium falciparum.
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Supercritical fluid technology for enhanced drug delivery and heterogeneous catalysis.
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The design and synthesis of anti-infective agents based on manzamine A.
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Sequence determinants and inhibition of the aggregation of the Alzheimer's Abeta peptide.
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Effect of gel strength on drug release from swellable matrices through polymer erosion.
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Hyaluronan-based synthetic extracellular matrices: Syntheses and applications.
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Novel polymeric structures and drug release mechanisms for cancer therapy.
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Discovery and selection of crystal forms facilitated by polymer-induced heteronucleation.
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Syntheses and applications of bisphosphonate-based biomaterials and nanomaterials.
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Modular approach toward multifunctional nanoparticles for integrated drug delivery, targeting, and diagnostics: Synthetic methods and practical applications.
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Oligo-L-lysine-, dextran-, and alkyl- derivatives of polyethylenimine for the development of novel gene transfection vectors.
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Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula.
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New methods for catalytic enantioselective conjugate addition of dialkylzinc reagents to alpha,beta-unsaturated carbonyls: Discovery and use of new catalysts.
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Biomimetic synthesis and mechanistic studies of natural product polysulfanes.
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Drug candidate discovery by high-throughput virtual screening of protein binding sites.
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Effects of solution parameters on the adsorption of proteins at interfaces.
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Preservation of two therapeutic biopharmaceuticals using sugars and polymers: Hematopoietic stem and progenitor cells and a live attenuated viral vaccine.
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Enantioselective tandem cyclopropanation/Cope rearrangement of heteroaryldiazoacetates and their applications in natural product synthesis.
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Enzymatic degradation of bovine serum Albumin nanoparticles for drug delivery.
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Self-assembled Rosette Nanotubes for Drug Delivery and Bone/Cartilage Tissue Regeneration.
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Studies in applied computational chemistry: META model of photochemical reactions under UV under natural conditions and an MCASE approach to the search of a cure for Parkinson's disease.
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Development of a specific pulmonary sustained delivery system for isoniazid.
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Computational studies of protein-ligand and protein-solvent interactions.
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Design, synthesis, and biological evaluation of new anti-cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of Chagas.
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Determination of an empirical correlation for the mass transfer coefficients of pharmaceutical powders in a fluid bed dryer.
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Optimization of drying-end-points measurements for the automation of a fluidized-bed dryer using FT-NIR spectroscopy.
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Raman-microscopy of individual cells and applications monitoring drug uptake.
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DNA specificity and biological impact of a platinum acridinylthiourea conjugate.
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Controlled release of insulin from a novel biodegradable injectable gel system.
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Nifedipine solid dispersion in microparticles of ethylcellulose and Eudragit RL binary blend for drug controlled delivery .
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Investigation of the effects of nanoparticles and apoptosis-inducing drugs on cells.
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Protein-based hydrogels self-assembled from genetically engineered triblock polypeptides containing coiled-coil domains.
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Total synthesis of DAQ-B1 and combinatorial synthesis of its analogues as potential anti-diabetic drugs.
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Studies toward the total syntheses of teicoplanin aglycon and cyclomarin A.
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Design, synthesis, and biological evaluation of molecules of medicinal interest: Inhibitors of mammalian and Trypanosoma cruzi protein farnesyltransferase and Trypanosoma cruzi lanosterol-14-alpha-demethylase.
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Total synthesis of luminacin D, isopanepoxydone, panepoxydone, and an isopanepoxydone derived biotinylated affinity reagent.
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Design, development and utilization of novel TAE descriptors and machine learning methods.
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Phytoceuticals from Hemerocallis flowers and roots with antioxidant, anticancer, mosquitocidal, and schistosome inhibitory activities.
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Introduction of structural perturbations into drug polymers: Effect on enzyme hydrolysis.
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Pharmaceutically engineered nanoparticles for (genetic) vaccine delivery.
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Inhibiting bacterial transglycosylases: From small molecules to a library of vancomycin analogs.
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An introduction to pharmaceutical sciences = production, chemistry, techniques and technology /
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Biotechnology and biopharmaceuticals = transforming proteins and genes into drugs /
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Ultrasonication assisted Layer-by-Layer technology for the preparation of multi-functional anticancer drugs paclitaxel and lapatinib.
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Quantification and identification of pharmaceuticals and their treatment by-products in drinking water and wastewater by LC/MS/MS.
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The reaction kinetics, crystal structures and novel inhibitors of bacterial OSB-CoA synthetase.
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Physical pharmacy : = physical chemical principles in the pharmaceutical sciences /
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Organic-chemical drugs and their synonyms : = (an international survey) /
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Mechanistic studies of novel sodium channel blockers for the treatment of epilepsy.
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Bifunctional polymeric conjugates for contrast-enhanced magnetic resonance imaging-guided noninvasive photodynamic therapy of cancer.
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The design and delivery of a biodegradable poly(lactic-co-glycolic) acid based carrier to the regional lymphatics in rats.
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Synthesis and characterization of a squaraine dye-folate complex for photodynamic therapy.
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Colon-targeted delivery of 9-aminocamptothecin by HPMA copolymer conjugates for the treatment of colon cancer.
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Preclinical exploration of novel small molecules as anticancer agents in triple-negative and HER2/neu-positive breast cancers.
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Ocular delivery of peptide ganciclovir prodrugs following subconjunctival injection: Evaluation of episcleral drug delivery approach.
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The effects of indirubin derivatives on gene expression and cellular functions in the murine cell line, RAW 264.7.
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Bioanalytical methods for investigating bacterial adhesion and the antibacterial action of nitric oxide.
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Engineering the nanoparticle surface for protein recognition and applications.
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Design and synthesis of bioactive small molecules and high-throughput identification of enantiomeric excess.
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Design and synthesis of small molecules and nanoparticle conjugates for cell type-selective delivery.
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Stereoselective metabolism and pharmacokinetics of ifosfamide in the rat.
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Identification and design of small molecules that associate with aggregated Alzheimer's-related beta-amyloid peptides.
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Clinical and pharmaceutical applications of high-performance affinity chromatography.
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Cellular uptake of cobalamin in clinically-derived blood samples, normal and cancerous brain cells.
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Elucidation of anti-proliferative and pro-apoptotic signaling induced by the immunomodulatory benzodiazepine Bz-423.
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Integration of pharmaceutical discovery and development = case histories /
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(Language materials, printed)
Skin aging handbook = an integrated approach to biochemistry and product development /
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