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Engineering the nanoparticle surface...

University of Massachusetts Amherst., Chemistry.

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Engineering the nanoparticle surface for protein recognition and applications.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Engineering the nanoparticle surface for protein recognition and applications./
作者:	De, Mrinmoy.
面頁冊數:	242 p.
附註:	Adviser: Vincent M. Rotello.
Contained By:	Dissertation Abstracts International70-06B.
標題:	Chemistry, Biochemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3359132
ISBN:	9781109189896

Engineering the nanoparticle surface for protein recognition and applications.
De, Mrinmoy.

Engineering the nanoparticle surface for protein recognition and applications. - 242 p.

Adviser: Vincent M. Rotello.

Thesis (Ph.D.)--University of Massachusetts Amherst, 2009.

Proteins and nanoparticles (NPs) provide a promising platform for supramolecular interaction. We are currently exploring both fundamental and applied aspects of this interaction. On the fundamental side, we have fabricated a series of water-soluble anionic and cationic NPs to interact with cationic and anionic proteins respectively. A Varity of studies such as, activity assay, fluorescence titration, isothermal titration calorimetry etc. were carried out to quantify the binding properties of these functional NPs with those proteins. Those studies reveal the prospect of tuning the affinity between the nanoparticles and proteins by the surface modification. On the application side, we have used this protein-nanoparticle interaction in protein refolding where we successfully refolded the thermally denatured proteins toward its native structure. We have also applied this particle-protein recognition to create a biocompatible protein sensor using a protein-NP conjugate. Green fluorescent protein and a series of cationic NPs were used for a protein sensor for the identification of protein analytes through displacement process. We have extended this application even in sensing the proteins in human serum.

ISBN: 9781109189896Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Engineering the nanoparticle surface for protein recognition and applications.
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