東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Synthetic studies on the kalihinane ...

Keaney, Gregg F.

FindBook

Google Book

Amazon

博客來

Synthetic studies on the kalihinane diterpenoids.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Synthetic studies on the kalihinane diterpenoids./
作者:	Keaney, Gregg F.
面頁冊數:	366 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5984.
Contained By:	Dissertation Abstracts International66-11B.
標題:	Chemistry, Organic. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3194669
ISBN:	9780542394348

Synthetic studies on the kalihinane diterpenoids.
Keaney, Gregg F.

Synthetic studies on the kalihinane diterpenoids. - 366 p.

Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5984.

Thesis (Ph.D.)--Yale University, 2005.

Kalihinol A (1) was isolated from the Guamanian marine sponge Acanthella cavernosa in 1984. To date, more than forty compounds (2-46) related to 1 have been isolated, and many of these highly-functionalized diterpenoids possess very unique biological activities. In particular, 1 has been shown to exhibit extremely potent antimalarial activity against Plasmodium falciparum.

ISBN: 9780542394348Subjects--Topical Terms:

516206
Chemistry, Organic.

Synthetic studies on the kalihinane diterpenoids.
LDR:02397nmm 2200289 4500 001 1828141
005 20061228142327.5
008 130610s2005 eng d
020 $a 9780542394348
035 $a (UnM)AAI3194669
035 $a AAI3194669
040 $a UnM $c UnM
100 1 $a Keaney, Gregg F. $3 1917046
245 1 0 $a Synthetic studies on the kalihinane diterpenoids.
300 $a 366 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-11, Section: B, page: 5984.
500 $a Director: John Louis Wood.
502 $a Thesis (Ph.D.)--Yale University, 2005.
520 $a Kalihinol A (1) was isolated from the Guamanian marine sponge Acanthella cavernosa in 1984. To date, more than forty compounds (2-46) related to 1 have been isolated, and many of these highly-functionalized diterpenoids possess very unique biological activities. In particular, 1 has been shown to exhibit extremely potent antimalarial activity against Plasmodium falciparum.
520 $a In light of the fascinating chemical structures and intriguing biological profile of members of the kalihinane family, a project directed towards the total synthesis of 1 and related kalihinanes has been conducted. In 2003, the first total synthesis of (+/-)-kalihinol C ((+/-)- 3) was accomplished, the synthetic strategy of which relied upon a series of substrate-controlled, diastereoselective reactions in order to functionalize the decalin core (66→67, 68→69, 77→82) and install the pendant tetrahydrofuran ring (82G→83, 82→84, 88→89 ). Current efforts in our laboratory have been focused upon the total synthesis of 1 with an emphasis upon improving the efficiency of the aziridination reaction (77→150a, 77→174) and the development of novel synthetic methodology. Such efforts have led to the application of rhodium (II) perfluorobutyramide (199) in conducting a variety of olefin aziridinations (200→202-4). Furthermore, a series of kalihinane analogs have been synthesized and assayed in an effort to understand the role of the kalihinane carbocycle and the isonitriles in antimalarial activity.
590 $a School code: 0265.
650 4 $a Chemistry, Organic. $3 516206
650 4 $a Chemistry, Pharmaceutical. $3 550957
690 $a 0490
690 $a 0491
710 2 0 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 66-11B.
790 1 0 $a Wood, John Louis, $e advisor
790 $a 0265
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3194669