東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Theoretical aspects of designing new...

Kucukkal, Tugba Gul.

FindBook

Google Book

Amazon

博客來

Theoretical aspects of designing new vaccines for breast cancer: Docking studies of peptide/HLA-A2.1 complexes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Theoretical aspects of designing new vaccines for breast cancer: Docking studies of peptide/HLA-A2.1 complexes./
作者:	Kucukkal, Tugba Gul.
面頁冊數:	62 p.
附註:	Source: Masters Abstracts International, Volume: 41-06, page: 1740.
Contained By:	Masters Abstracts International41-06.
標題:	Chemistry, Pharmaceutical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1414197

Theoretical aspects of designing new vaccines for breast cancer: Docking studies of peptide/HLA-A2.1 complexes.
Kucukkal, Tugba Gul.

Theoretical aspects of designing new vaccines for breast cancer: Docking studies of peptide/HLA-A2.1 complexes. - 62 p.

Source: Masters Abstracts International, Volume: 41-06, page: 1740.

Thesis (M.S.)--Duquesne University, 2003.

HER2/<italic>neu</italic> is a transmembrane glycoprotein that is overexpressed in many tumors, including ovarian and breast cancers. The HER2/<italic>neu </italic> peptide IISAVVGIL (GP2) is recognized by tumor-specific cytotoxic T lymphocytes in the context of human class I major histocompatibility complex (MHC) HLA-A2.1. One limiting-factor for using GP2 as a tumor vaccine is its poor affinity for HLA-A2.1, even though it has the correct peptide-binding motif. The research aims are to develop an accurate docking method for the binding of GP2 to HLA-A2.1, to understand the molecular forces that give rise to strong binding, and to predict mutations that lead to new tumor vaccines. AutoDock and GOLD have been used for docking calculations. The binding free energies from AutoDock correlate qualitatively with experiment. The docked structures for 14 ligands from Autodock3 are in good agreement with experiment. However, the ligands are not fully flexible. GOLD allowed full flexibility to reproduce experimental GP2 structure.Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

Theoretical aspects of designing new vaccines for breast cancer: Docking studies of peptide/HLA-A2.1 complexes.
LDR:01956nmm 2200289 4500 001 1858979
005 20041020095008.5
008 130614s2003 eng d
035 $a (UnM)AAI1414197
035 $a AAI1414197
040 $a UnM $c UnM
100 1 $a Kucukkal, Tugba Gul. $3 1946645
245 1 0 $a Theoretical aspects of designing new vaccines for breast cancer: Docking studies of peptide/HLA-A2.1 complexes.
300 $a 62 p.
500 $a Source: Masters Abstracts International, Volume: 41-06, page: 1740.
500 $a Supervisor: Jeffrey D. Evanseck.
502 $a Thesis (M.S.)--Duquesne University, 2003.
520 $a HER2/<italic>neu</italic> is a transmembrane glycoprotein that is overexpressed in many tumors, including ovarian and breast cancers. The HER2/<italic>neu </italic> peptide IISAVVGIL (GP2) is recognized by tumor-specific cytotoxic T lymphocytes in the context of human class I major histocompatibility complex (MHC) HLA-A2.1. One limiting-factor for using GP2 as a tumor vaccine is its poor affinity for HLA-A2.1, even though it has the correct peptide-binding motif. The research aims are to develop an accurate docking method for the binding of GP2 to HLA-A2.1, to understand the molecular forces that give rise to strong binding, and to predict mutations that lead to new tumor vaccines. AutoDock and GOLD have been used for docking calculations. The binding free energies from AutoDock correlate qualitatively with experiment. The docked structures for 14 ligands from Autodock3 are in good agreement with experiment. However, the ligands are not fully flexible. GOLD allowed full flexibility to reproduce experimental GP2 structure.
590 $a School code: 0067.
650 4 $a Chemistry, Pharmaceutical. $3 550957
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Chemistry, Physical. $3 560527
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0491
690 $a 0487
690 $a 0494
690 $a 0992
710 2 0 $a Duquesne University. $3 1017927
773 0 $t Masters Abstracts International $g 41-06.
790 1 0 $a Evanseck, Jeffrey D., $e advisor
790 $a 0067
791 $a M.S.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1414197