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Identification and design of small m...

University of California, San Diego., Chemistry.

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Identification and design of small molecules that associate with aggregated Alzheimer's-related beta-amyloid peptides.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Identification and design of small molecules that associate with aggregated Alzheimer's-related beta-amyloid peptides./
作者:	Bautista, Mahealani Roberts.
面頁冊數:	220 p.
附註:	Adviser: Jerry Yang.
Contained By:	Dissertation Abstracts International70-02B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3344755
ISBN:	9781109039504

Identification and design of small molecules that associate with aggregated Alzheimer's-related beta-amyloid peptides.
Bautista, Mahealani Roberts.

Identification and design of small molecules that associate with aggregated Alzheimer's-related beta-amyloid peptides. - 220 p.

Adviser: Jerry Yang.

Thesis (Ph.D.)--University of California, San Diego, 2009.

Aggregated beta-amyloid peptides have been identified as a pathological hallmark of Alzheimer's Disease (AD). Presented in this dissertation is the identification, evaluation, and design of small molecules that bind to aggregated beta-amyloid peptides. First, this dissertation describes the development of a parallel assay to rapidly screen small- to medium-sized libraries of molecules for their ability to bind to aggregated beta-amyloid(1-42) peptides. It also describes the extension of this assay to identify molecules that associate with two other amyloidogenic peptides, beta-amyloid(1-40) and alpha-synuclein(1-140), which revealed some selectivity for the association of specific small molecules to different amyloids. Second, it describes the development of amyloid-binding molecules that are capable of inhibiting protein-amyloid interactions, which may lead to a new therapeutic strategy for combating amyloid-based neurodegenerative disorders. Specifically, it describes the synthesis and evaluation of derivatives of thioflavin T, nicotine, and dopamine for their ability to inhibit protein-amyloid interactions. An extensive evaluation of derivatives of dopamine revealed the minimum structural requirements necessary to effectively inhibit the interaction between aggregated beta-amyloid peptides. Lastly, it describes studies towards the rational design of a novel class of imaging agents for AD based on information from the structure-binding studies with derivatives of dopamine.

ISBN: 9781109039504Subjects--Topical Terms:

586156
Chemistry, Analytical.

Identification and design of small molecules that associate with aggregated Alzheimer's-related beta-amyloid peptides.
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