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Discovery and selection of crystal f...

Grzesiak, Adam L.

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Discovery and selection of crystal forms facilitated by polymer-induced heteronucleation.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Discovery and selection of crystal forms facilitated by polymer-induced heteronucleation./
作者:	Grzesiak, Adam L.
面頁冊數:	107 p.
附註:	Adviser: Adam J. Matzger.
Contained By:	Dissertation Abstracts International68-08B.
標題:	Chemistry, Pharmaceutical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3276169
ISBN:	9780549174042

Discovery and selection of crystal forms facilitated by polymer-induced heteronucleation.
Grzesiak, Adam L.

Discovery and selection of crystal forms facilitated by polymer-induced heteronucleation. - 107 p.

Adviser: Adam J. Matzger.

Thesis (Ph.D.)--University of Michigan, 2007.

Polymorphism, the existence of a substance as two or more crystalline phases that differ solely in arrangements and/or conformations of the molecules in the crystal lattice, exerts a profound effect on the properties of materials. Despite the importance of controlling the crystalline form of compounds, no general method exists for producing all of the energetically reasonable polymorphs of a given compound. With the aim of controlling form production by heterogeneous nucleation, chemically diverse surfaces composed of polymers, either commercially available or synthesized utilizing combinatorial methods, were employed as heteronuclei during crystallization.

ISBN: 9780549174042Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

Discovery and selection of crystal forms facilitated by polymer-induced heteronucleation.
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245 1 0 $a Discovery and selection of crystal forms facilitated by polymer-induced heteronucleation.
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520 $a Polymorphism, the existence of a substance as two or more crystalline phases that differ solely in arrangements and/or conformations of the molecules in the crystal lattice, exerts a profound effect on the properties of materials. Despite the importance of controlling the crystalline form of compounds, no general method exists for producing all of the energetically reasonable polymorphs of a given compound. With the aim of controlling form production by heterogeneous nucleation, chemically diverse surfaces composed of polymers, either commercially available or synthesized utilizing combinatorial methods, were employed as heteronuclei during crystallization.
520 $a The polymer-induced heteronucleation approach facilitated the discovery of new crystal forms of the pharmaceuticals sulindac and flurbiprofen and the platinum complex Pt(phen)Cl2, all of which were inaccessible by other techniques. Moreover, selective production of known forms was also achieved and this facilitated determination of the thermodynamic relationship among polymorphs in each system. This approach resulted in the discovery of novel extended networks, each derived from a different linking unit, utilizing conditions optimized for the production of a different and previously reported network. This approach was also successful at the selective nucleation of multiple crystal forms of the protein hen egg white lysozyme from a single condition by changing the polymer heteronucleus, which was only previously achieved by changing the concentration, buffer, precipitant, pH, and/or temperature. Therefore, this method could be employed to grow single crystals of multiple forms of macromolecules to better explore the effect packing has on observed protein structure.
520 $a In all cases, selectivity for a given crystal form could be achieved by optimizing conditions identified during screening experiments, which were generally highly dependent on the chemistry of the polymer heteronucleus. An additional feature of this approach was the production of single crystals suitable for structure determination of both known and previously unknown crystal forms, which enabled accurate phase identification and also offered a glimpse into the relationship between solid-state structure and stability. Thus, the polymer-induced heteronucleation approach represents an additional diversity element during crystallization with the ability to screen by standard high throughput techniques.
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