東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Syntheses and applications of bispho...

Wang, Ling.

FindBook

Google Book

Amazon

博客來

Syntheses and applications of bisphosphonate-based biomaterials and nanomaterials.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Syntheses and applications of bisphosphonate-based biomaterials and nanomaterials./
作者:	Wang, Ling.
面頁冊數:	124 p.
附註:	Adviser: Bing Xu.
Contained By:	Dissertation Abstracts International68-10B.
標題:	Chemistry, Biochemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3285727
ISBN:	9780549283638

Syntheses and applications of bisphosphonate-based biomaterials and nanomaterials.
Wang, Ling.

Syntheses and applications of bisphosphonate-based biomaterials and nanomaterials. - 124 p.

Adviser: Bing Xu.

Thesis (Ph.D.)--Hong Kong University of Science and Technology (Hong Kong), 2007.

In this thesis, we designed and synthesized novel biomaterials and nanomaterials based on bisphosphonates which had good expanding applications besides therapeutic use as traditional bisphosphonates. It contains five chapters. In chapter 2, we reported the design and synthesis of a new monomer, N-acryl pamidronate and its crosslinked copolymer with N-isopropylacrylamide can form a hydrogel which served well as the substrate to direct the formation of hydroxyapatites. And in chapter 3, we designed and synthesized a novel pamidronate derivative, Nap-FF-Pamidronate, which showed a better bone anti-resorptive effect by accelerating the new cortical endosteal bone formation than pamidronate did in an osteoporosis model using mouse. Since it can self-assemble to form a supramolecular hydrogel, we think our self-assemble system might turn to be a new approach to design new bisphosphonate to treat bone resorption diseases. In chapter 4, we designed and used bisphosphonate modified nanoparticles to remove uranyl ion in water and blood with high specificity and efficiency, which promise a sensitive and rapid platform to the detection, recovery, and rapid decorporation of metal toxins from biological environment via tailoring the ligands. In chapter 5, we described the use of a pamidronate-containing supramolecular hydrogel for decorporation of uranium. The efficacy of the hydrogels was evaluated using a rat model in which rats were contaminated by injection of uranyl nitrate into their stomach. In chapter 6, the enzymatic conversion of porphyrin dityrosine phosphates promises a new, useful approach to enhance the photodynamic therapy (PDT) effect for treatment of cancers.

ISBN: 9780549283638Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Syntheses and applications of bisphosphonate-based biomaterials and nanomaterials.
LDR:02617nam 2200289 a 45 001 957391
005 20110630
008 110630s2007 ||||||||||||||||| ||eng d
020 $a 9780549283638
035 $a (UMI)AAI3285727
035 $a AAI3285727
040 $a UMI $c UMI
100 1 $a Wang, Ling. $3 519909
245 1 0 $a Syntheses and applications of bisphosphonate-based biomaterials and nanomaterials.
300 $a 124 p.
500 $a Adviser: Bing Xu.
500 $a Source: Dissertation Abstracts International, Volume: 68-10, Section: B, page: 6651.
502 $a Thesis (Ph.D.)--Hong Kong University of Science and Technology (Hong Kong), 2007.
520 $a In this thesis, we designed and synthesized novel biomaterials and nanomaterials based on bisphosphonates which had good expanding applications besides therapeutic use as traditional bisphosphonates. It contains five chapters. In chapter 2, we reported the design and synthesis of a new monomer, N-acryl pamidronate and its crosslinked copolymer with N-isopropylacrylamide can form a hydrogel which served well as the substrate to direct the formation of hydroxyapatites. And in chapter 3, we designed and synthesized a novel pamidronate derivative, Nap-FF-Pamidronate, which showed a better bone anti-resorptive effect by accelerating the new cortical endosteal bone formation than pamidronate did in an osteoporosis model using mouse. Since it can self-assemble to form a supramolecular hydrogel, we think our self-assemble system might turn to be a new approach to design new bisphosphonate to treat bone resorption diseases. In chapter 4, we designed and used bisphosphonate modified nanoparticles to remove uranyl ion in water and blood with high specificity and efficiency, which promise a sensitive and rapid platform to the detection, recovery, and rapid decorporation of metal toxins from biological environment via tailoring the ligands. In chapter 5, we described the use of a pamidronate-containing supramolecular hydrogel for decorporation of uranium. The efficacy of the hydrogels was evaluated using a rat model in which rats were contaminated by injection of uranyl nitrate into their stomach. In chapter 6, the enzymatic conversion of porphyrin dityrosine phosphates promises a new, useful approach to enhance the photodynamic therapy (PDT) effect for treatment of cancers.
590 $a School code: 1223.
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Chemistry, Pharmaceutical. $3 550957
650 4 $a Chemistry, Polymer. $3 1018428
690 $a 0487
690 $a 0491
690 $a 0495
710 2 $a Hong Kong University of Science and Technology (Hong Kong). $3 1022235
773 0 $t Dissertation Abstracts International $g 68-10B.
790 $a 1223
790 1 0 $a Xu, Bing, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3285727