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Supercritical fluid technology for e...

Pathak, Pankaj.

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Supercritical fluid technology for enhanced drug delivery and heterogeneous catalysis.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Supercritical fluid technology for enhanced drug delivery and heterogeneous catalysis./
作者:	Pathak, Pankaj.
面頁冊數:	221 p.
附註:	Adviser: Ya-Ping Sun.
Contained By:	Dissertation Abstracts International67-11B.
標題:	Chemistry, Pharmaceutical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3240464
ISBN:	9780542948541

Supercritical fluid technology for enhanced drug delivery and heterogeneous catalysis.
Pathak, Pankaj.

Supercritical fluid technology for enhanced drug delivery and heterogeneous catalysis. - 221 p.

Adviser: Ya-Ping Sun.

Thesis (Ph.D.)--Clemson University, 2006.

In recent years there has been great interest in the properties of supercritical fluids (SCFs) and applications of supercritical fluid technology in chemistry, material sciences and many other areas. In our laboratory, we have applied supercritical fluid namely CO2, as a medium for pharmaceutical processing and also for heterogeneous catalysis. The method used for pharmaceutical processing is based on the Rapid Expansion of supercritical solutions into a liquid SOLVent (RESOLV). We have used this method for the preparation of nanoparticles from various anti-inflammatory (Ibuprofen and Naproxen), anti-fungal (Amphotericin B) and anti-cancer (Paclitaxel) drugs. The anticancer drug nanoparticle formulations were further used for in vitro biological evaluation. In this dissertation, results from the preparation, characterization and biological evaluation of nanoscale drug particles are reported. The effect of experimental conditions on the properties of the nanoparticles prepared via our RESOLV method is discussed. In addition we have used supercritical CO2 as a medium for photoreduction of CO2 using dispersed TiO 2 or metal coated-TiO2 nanoparticles encapsulated in nanoscale cavities of perfluorinated ionomer membranes. These catalytic films are also stable chemically and photochemically, reusable in repeated reactions. The results from the characterization of the nanoparticles and the use of films using different catalysts are presented and discussed.

ISBN: 9780542948541Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

Supercritical fluid technology for enhanced drug delivery and heterogeneous catalysis.
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