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Bioavailability of the tea flavonoid...

Vaidyanathan, Jayabharathi.

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Bioavailability of the tea flavonoids epicatechin and epicatechin gallate: Role of membrane transport and metabolism.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Bioavailability of the tea flavonoids epicatechin and epicatechin gallate: Role of membrane transport and metabolism./
作者:	Vaidyanathan, Jayabharathi.
面頁冊數:	157 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3211.
Contained By:	Dissertation Abstracts International64-07B.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3098199
ISBN:	049645811X

Bioavailability of the tea flavonoids epicatechin and epicatechin gallate: Role of membrane transport and metabolism.
Vaidyanathan, Jayabharathi.

Bioavailability of the tea flavonoids epicatechin and epicatechin gallate: Role of membrane transport and metabolism. - 157 p.

Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3211.

Thesis (Ph.D.)--Medical University of South Carolina, 2003.

Tea flavonoids, including (-)-epicatechin (EC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin gallate (EGCG) and (-)-epigallocatechin (EGC) have been shown to have chemopreventive activity in cancer. Studies in animals and humans suggest t

ISBN: 049645811XSubjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Bioavailability of the tea flavonoids epicatechin and epicatechin gallate: Role of membrane transport and metabolism.
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245 1 0 $a Bioavailability of the tea flavonoids epicatechin and epicatechin gallate: Role of membrane transport and metabolism.
300 $a 157 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3211.
500 $a Adviser: Thomas Walle.
502 $a Thesis (Ph.D.)--Medical University of South Carolina, 2003.
520 $a Tea flavonoids, including (-)-epicatechin (EC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin gallate (EGCG) and (-)-epigallocatechin (EGC) have been shown to have chemopreventive activity in cancer. Studies in animals and humans suggest t
520 $a We used the Caco-2 cell monolayers, a well-established model to study human intestinal absorption together with molecularly-specific HPLC to characterize the transport of EC and ECG. We found that EC showed a direction dependency in transport, w
520 $a In contrast to EC, when cell uptake studies were done using its corresponding gallate ECG, it was very efficiently transported across the apical membrane of the Caco-2 cells by a pH-dependent mechanism presumably by the monocarboxylate transport
520 $a Thus, the work described in this dissertation helps to understand the mechanisms governing the intestinal absorption of dietary catechins. This work has also helped identify the major site of action of these flavonoids. The observations made dem
590 $a School code: 0122.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Chemistry, Pharmaceutical. $3 550957
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710 2 0 $a Medical University of South Carolina. $3 700119
773 0 $t Dissertation Abstracts International $g 64-07B.
790 1 0 $a Walle, Thomas, $e advisor
790 $a 0122
791 $a Ph.D.
792 $a 2003
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