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Associations of dietary fats and vit...

Mehta, Niyati Ramesh.

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Associations of dietary fats and vitamin D with age-related maculopathy in population studies.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Associations of dietary fats and vitamin D with age-related maculopathy in population studies./
作者:	Mehta, Niyati Ramesh.
面頁冊數:	219 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6533.
Contained By:	Dissertation Abstracts International66-12B.
標題:	Health Sciences, Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3200075
ISBN:	9780542468360

Associations of dietary fats and vitamin D with age-related maculopathy in population studies.
Mehta, Niyati Ramesh.

Associations of dietary fats and vitamin D with age-related maculopathy in population studies. - 219 p.

Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6533.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2005.

Total or specific types of dietary fats have been hypothesized to increase the risk of age-related maculopathy (ARM) through several potential biologic mechanisms. Existing epidemiologic evidence is sparse and inconsistent for the relationship between ARM and dietary fat, specifically for types of fats, with the exception of intakes of o-3 polyunsaturated fat, present in fish, which is generally supportive of a protective association, especially for advanced stages. Vitamin D, naturally present in high levels in fish, may be an alternate explanation for previously observed inverse associations.

ISBN: 9780542468360Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Associations of dietary fats and vitamin D with age-related maculopathy in population studies.
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500 $a Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6533.
500 $a Supervisor: Julie A. Mares.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2005.
520 $a Total or specific types of dietary fats have been hypothesized to increase the risk of age-related maculopathy (ARM) through several potential biologic mechanisms. Existing epidemiologic evidence is sparse and inconsistent for the relationship between ARM and dietary fat, specifically for types of fats, with the exception of intakes of o-3 polyunsaturated fat, present in fish, which is generally supportive of a protective association, especially for advanced stages. Vitamin D, naturally present in high levels in fish, may be an alternate explanation for previously observed inverse associations.
520 $a We investigated relationships of (1) amount and type of dietary fat, and (2) serum vitamin D and ARM, using an epidemiologic approach. In the first study, dietary intake of total and specific types of fats was estimated using a food frequency questionnaire (1994-98), and age-related macular degeneration (AMD) was ascertained using retinal photographs approximately seven years later (2001-2003). We noted that total fats were not associated with intermediate AMD in the overall population. However, associations differed by age. Total fat intake was associated with increased risk of intermediate AMD in women <75 years, which represented about three fourths of our population. Differently, we observed a decreased risk for AMD in women ≥75 years. Types of fat were associated differently with intermediate AMD: women with diets high in o-6 PUFA and o-3 PUFA had increased prevalence of intermediate AMD, whereas women with diets high in MUFA had a decreased prevalence of intermediate AMD.
520 $a Our second study was conducted to evaluate the associations between ARM and vitamin D, a fat-soluble nutrient. Recent reports have focused on the role of inflammation in the pathogenesis of early ARM. The anti-inflammatory properties of vitamin D suggest that higher vitamin D may be protective against ARM. We undertook this study in the Third National Health and Nutrition Examination Survey (NHANES III; N = 7,648). Our results suggest that increasing levels of serum vitamin D are inversely associated with overall early ARM. Since we provided the first scientific evidence of the associations of vitamin D and ARM, further investigations in prospective studies are needed for confirmation of these associations.
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