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Adiposity and its relationship to mo...

Moore, Steven C.

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Adiposity and its relationship to mortality and to cancer: Challenges and new approaches.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Adiposity and its relationship to mortality and to cancer: Challenges and new approaches./
Author:	Moore, Steven C.
Description:	103 p.
Notes:	Adviser: Susan T. Mayne.
Contained By:	Dissertation Abstracts International68-06B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3267324
ISBN:	9780549068600

Adiposity and its relationship to mortality and to cancer: Challenges and new approaches.
Moore, Steven C.

Adiposity and its relationship to mortality and to cancer: Challenges and new approaches. - 103 p.

Adviser: Susan T. Mayne.

Thesis (Ph.D.)--Yale University, 2007.

Background. Due to rising prevalence of overweight and obesity throughout the world, understanding the health effects of adiposity has become increasingly urgent. While excess weight has been linked to increased incidence of cardiovascular disease, diabetes, and cancers of the colon, breast, and other sites, many aspects of the relationship between adiposity and health remain controversial. Novel analytical strategies, including molecular epidemiological approaches, may help resolve these debates.

ISBN: 9780549068600Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Adiposity and its relationship to mortality and to cancer: Challenges and new approaches.
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100 1 $a Moore, Steven C. $3 1285659
245 1 0 $a Adiposity and its relationship to mortality and to cancer: Challenges and new approaches.
300 $a 103 p.
500 $a Adviser: Susan T. Mayne.
500 $a Source: Dissertation Abstracts International, Volume: 68-06, Section: B, page: 3728.
502 $a Thesis (Ph.D.)--Yale University, 2007.
520 $a Background. Due to rising prevalence of overweight and obesity throughout the world, understanding the health effects of adiposity has become increasingly urgent. While excess weight has been linked to increased incidence of cardiovascular disease, diabetes, and cancers of the colon, breast, and other sites, many aspects of the relationship between adiposity and health remain controversial. Novel analytical strategies, including molecular epidemiological approaches, may help resolve these debates.
520 $a Methods. This dissertation contains three separate parts related to adiposity and its health effects. Study I is a prospective cohort analysis of the relationship between body mass index (BMI) and mortality. The cohort consists of 50,186 women from a breast cancer screening project who responded to a follow-up questionnaire mailed 10 years after the screening project ended. Participants were followed from the date that the questionnaire was returned (baseline) and BMI was based on technician-measured weight and height during screening (i.e. 10 years prior to baseline). We hypothesized that a BMI assessed in the past may mitigate bias due to reverse causation. Study II, using the same cohort, compares the association of past BMI and mortality (per Study I), with that of current BMI and usual adult BMI, as reported on the baseline questionnaire. In Study III, we investigated variants in genes related to insulin resistance and hyperinsulinemia (hypothesized biological mediators of the effects of excess weight) and their relationship to cancer and to serum insulin levels.
520 $a Results. Study I and II: Using past BMI, we found that modest overweight (BMI 25--29.9) and obesity (BMI 30+) were associated with increased mortality regardless of age, history of cardiovascular disease or cancer, or smoking status. In contrast, using BMI at baseline, overweight was associated with reduced mortality. Study III: We did not find an association between variants in insulin resistance related genes and prostate cancer or serum insulin.
520 $a Conclusions. The relationship between BMI and mortality varies depending on when and how BMI is assessed. Weights in the past resulted in stronger associations with mortality, perhaps due to removal of reverse causation. Variants in insulin-resistance genes were not associated with prostate cancer or serum insulin.
590 $a School code: 0265.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Health Sciences, Public Health. $3 1017659
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710 2 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 68-06B.
790 $a 0265
790 1 0 $a Mayne, Susan T., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3267324