東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Analysis of the role of gene regulat...

Sethupathy, Praveen.

Linked to FindBook

Google Book

Amazon

博客來

Analysis of the role of gene regulatory elements in human health and evolution.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Analysis of the role of gene regulatory elements in human health and evolution./
Author:	Sethupathy, Praveen.
Description:	145 p.
Notes:	Adviser: S. Hannenhalli.
Contained By:	Dissertation Abstracts International69-04B.
Subject:	Biology, Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3309505
ISBN:	9780549577966

Analysis of the role of gene regulatory elements in human health and evolution.
Sethupathy, Praveen.

Analysis of the role of gene regulatory elements in human health and evolution. - 145 p.

Adviser: S. Hannenhalli.

Thesis (Ph.D.)--University of Pennsylvania, 2008.

When the first draft of the human genome was published, scientists labeled all non-genic regions (>95% of the genome) as "junk DNA" since they were not predicted to encode for proteins, the molecular building blocks of life. This proved to be a hasty conclusion because it turns out that much of what was considered to be "junk" comprises important functional elements, such as transposons, retrotransposons, non-coding RNAs, and gene regulatory elements (GREs). "Junk" DNA is now simply referred to as "non-coding DNA" to indicate that though they are not expected to encode for protein, they may indeed still serve some important function.

ISBN: 9780549577966Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Analysis of the role of gene regulatory elements in human health and evolution.
LDR:02963nam 2200313 a 45 001 951292
005 20110609
008 110609s2008 ||||||||||||||||| ||eng d
020 $a 9780549577966
035 $a (UMI)AAI3309505
035 $a AAI3309505
040 $a UMI $c UMI
100 1 $a Sethupathy, Praveen. $3 1275272
245 1 0 $a Analysis of the role of gene regulatory elements in human health and evolution.
300 $a 145 p.
500 $a Adviser: S. Hannenhalli.
500 $a Source: Dissertation Abstracts International, Volume: 69-04, Section: B, page: 2031.
502 $a Thesis (Ph.D.)--University of Pennsylvania, 2008.
520 $a When the first draft of the human genome was published, scientists labeled all non-genic regions (>95% of the genome) as "junk DNA" since they were not predicted to encode for proteins, the molecular building blocks of life. This proved to be a hasty conclusion because it turns out that much of what was considered to be "junk" comprises important functional elements, such as transposons, retrotransposons, non-coding RNAs, and gene regulatory elements (GREs). "Junk" DNA is now simply referred to as "non-coding DNA" to indicate that though they are not expected to encode for protein, they may indeed still serve some important function.
520 $a Francis Crick's central dogma of molecular biology provides the now standard pathway of gene activation. It states that a gene (a DNA subsequence of the genome) is first transcribed into messenger RNA (mRNA) which is in turn translated into protein. A subset of GREs, often referred to as cis-elements, are involved in regulating the transcriptional and translational aspects of gene activation. In 1975, King & Wilson speculated that differences in gene activation patterns underlie phenotypic (observable physical or biochemical characteristics) variation within and between species [1]. With the advent of large-scale computational and experimental techniques for the identification of GREs it is becoming increasingly tractable to test their speculation.
520 $a In this thesis, I present computational techniques for the genome-wide identification of a sub-class of GREs known as microRNA target sites, and evidences for their important role in human health and disease. Further, I also describe and discuss the results of a quantitative population genomics approach to analyze human population patterns of sequence variation in another sub-class of GREs known as transcription factor binding sites (TFBSs). These results extend current knowledge of the role of GREs in human evolution, and also point to the importance of continued research in the area of evolution of gene regulation.
590 $a School code: 0175.
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Computer Science. $3 626642
690 $a 0369
690 $a 0715
690 $a 0984
710 2 $a University of Pennsylvania. $3 1017401
773 0 $t Dissertation Abstracts International $g 69-04B.
790 $a 0175
790 1 0 $a Hannenhalli, S., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3309505