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Computational approaches to the mode...

Ruan, Jianhua.

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Computational approaches to the modeling and analysis of biological networks.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Computational approaches to the modeling and analysis of biological networks./
Author:	Ruan, Jianhua.
Description:	256 p.
Notes:	Adviser: Weixiong Zhang.
Contained By:	Dissertation Abstracts International68-09B.
Subject:	Biology, Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3282436
ISBN:	9780549246534

Computational approaches to the modeling and analysis of biological networks.
Ruan, Jianhua.

Computational approaches to the modeling and analysis of biological networks. - 256 p.

Adviser: Weixiong Zhang.

Thesis (Ph.D.)--Washington University in St. Louis, 2007.

Cell functions are regulated by the network of interactions among different components in the cell, such as genes, proteins, and small regulatory RNAs. Although biological and biomedical researchers have successfully identified most of the components and many of the interactions, unfortunately, these collections of components and interactions do not offer convincing concepts to understand the functions and behaviors of biological systems. In this dissertation, we develop computational tools to model and analyze biological networks, and to study biomolecular functions in the context of biological networks. Specifically, we make contributions in two important areas.

ISBN: 9780549246534Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Computational approaches to the modeling and analysis of biological networks.
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005 20110524
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020 $a 9780549246534
035 $a (UMI)AAI3282436
035 $a AAI3282436
040 $a UMI $c UMI
100 1 $a Ruan, Jianhua. $3 1271178
245 1 0 $a Computational approaches to the modeling and analysis of biological networks.
300 $a 256 p.
500 $a Adviser: Weixiong Zhang.
500 $a Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 6084.
502 $a Thesis (Ph.D.)--Washington University in St. Louis, 2007.
520 $a Cell functions are regulated by the network of interactions among different components in the cell, such as genes, proteins, and small regulatory RNAs. Although biological and biomedical researchers have successfully identified most of the components and many of the interactions, unfortunately, these collections of components and interactions do not offer convincing concepts to understand the functions and behaviors of biological systems. In this dissertation, we develop computational tools to model and analyze biological networks, and to study biomolecular functions in the context of biological networks. Specifically, we make contributions in two important areas.
520 $a First, we develop and apply data mining methods to model gene transcriptional regulatory networks by integrating information from multiple sources. We extensively study the performance and capability of decision-tree methods in reconstructing transcriptional regulatory networks in the budding yeast. We also propose a multivariate regression tree method, called Bi-dimensional Regression Tree (BDTree), which can model gene transcription using cis regulatory elements and transcriptional regulators simultaneously.
520 $a Second, we develop computational algorithms for detecting the so-called community structures, which are important structural and functional elements of many complex networks including biological and social networks, and apply the algorithms to relate the structural properties of biological networks to the functions of bimolecules. We show that our algorithms have significantly advanced the state of the art in automatic community discovery. We demonstrate the advantages of our algorithms with several biological applications in analyzing gene expression microarray data and protein-protein interaction networks.
590 $a School code: 0252.
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Computer Science. $3 626642
690 $a 0715
690 $a 0984
710 2 $a Washington University in St. Louis. $3 1017519
773 0 $t Dissertation Abstracts International $g 68-09B.
790 $a 0252
790 1 0 $a Zhang, Weixiong, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3282436