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Escherichia coli proteomics and bioi...

Niu, Lili.

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Escherichia coli proteomics and bioinformatics.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Escherichia coli proteomics and bioinformatics./
Author:	Niu, Lili.
Description:	214 p.
Notes:	Adviser: James C. Hu.
Contained By:	Dissertation Abstracts International68-06B.
Subject:	Biology, Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3270376
ISBN:	9780549094555

Escherichia coli proteomics and bioinformatics.
Niu, Lili.

Escherichia coli proteomics and bioinformatics. - 214 p.

Adviser: James C. Hu.

Thesis (Ph.D.)--Texas A&M University, 2007.

A lot of things happen to proteins when Escherichia coli cells enter stationary phase, such as protein amount, post-translational modifications, conformation changes, and component of protein complex. Proteomics, which study the whole component of proteins, can be used to study the products of the genome and the physiology of Escherichia coli cells at different conditions. By comparing proteome from different growth phases, such as exponential and stationary phase, a lot of proteins with changes can be identified at the same time, which provides a pilot for further studies of mechanism.

ISBN: 9780549094555Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Escherichia coli proteomics and bioinformatics.
LDR:02351nam 2200277 a 45 001 947637
005 20110524
008 110524s2007 ||||||||||||||||| ||eng d
020 $a 9780549094555
035 $a (UMI)AAI3270376
035 $a AAI3270376
040 $a UMI $c UMI
100 1 $a Niu, Lili. $3 1271105
245 1 0 $a Escherichia coli proteomics and bioinformatics.
300 $a 214 p.
500 $a Adviser: James C. Hu.
500 $a Source: Dissertation Abstracts International, Volume: 68-06, Section: B, page: 3483.
502 $a Thesis (Ph.D.)--Texas A&M University, 2007.
520 $a A lot of things happen to proteins when Escherichia coli cells enter stationary phase, such as protein amount, post-translational modifications, conformation changes, and component of protein complex. Proteomics, which study the whole component of proteins, can be used to study the products of the genome and the physiology of Escherichia coli cells at different conditions. By comparing proteome from different growth phases, such as exponential and stationary phase, a lot of proteins with changes can be identified at the same time, which provides a pilot for further studies of mechanism.
520 $a Current global proteomic studies have identified about 27% of the annotated proteins of E. coli, most of which are predicted to be abundance proteins. Subproteomics, the study of specific subsets of the proteome, can be used to study specific functional classes of proteins and low abundance proteins. In this dissertation, using non-denatured anion exchange column with 2D SDS-PAGE and tandem mass spectrometry, difference of E. coli cells between exponential and stationary phase were studied for whole soluble proteome. Also, using heparin column and mass spectrometry with tandem mass spectrometry, heparin-binding proteins were identified and analyzed for exponential growth and stationary phases. To manage and display the data generated by proteomics, a web-based database has been constructed for experiments in E. coli proteomics (EEP), which includes NonDeLC, Heparome, AIX/2D PAGE and other proteomic studies.
590 $a School code: 0803.
650 4 $a Biology, Bioinformatics. $3 1018415
690 $a 0715
710 2 $a Texas A&M University. $3 718977
773 0 $t Dissertation Abstracts International $g 68-06B.
790 $a 0803
790 1 0 $a Hu, James C., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3270376