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In vitro selection of synthetic ligands.

Wrenn, Stephen Jarrett.

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In vitro selection of synthetic ligands.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	In vitro selection of synthetic ligands./
Author:	Wrenn, Stephen Jarrett.
Description:	121 p.
Notes:	Adviser: Pehr B. Harbury.
Contained By:	Dissertation Abstracts International68-12B.
Subject:	Biology, Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3292431
ISBN:	9780549357230

In vitro selection of synthetic ligands.
Wrenn, Stephen Jarrett.

In vitro selection of synthetic ligands. - 121 p.

Adviser: Pehr B. Harbury.

Thesis (Ph.D.)--Stanford University, 2008.

In 1967, the field of in vitro evolution was born when Spiegelman and coworkers demonstrated the first "extracellular Darwinian experiment". In vitro evolution strategies are now used routinely to isolated biopolymers with desired functional properties. In more recent years, our lab and others have been interested in applying evolution-based search strategies to synthetic compounds, as doing so could radically simplify small-molecule discovery, with applications in countless fields.

ISBN: 9780549357230Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

In vitro selection of synthetic ligands.
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020 $a 9780549357230
035 $a (UMI)AAI3292431
035 $a AAI3292431
040 $a UMI $c UMI
100 1 $a Wrenn, Stephen Jarrett. $3 1266961
245 1 0 $a In vitro selection of synthetic ligands.
300 $a 121 p.
500 $a Adviser: Pehr B. Harbury.
500 $a Source: Dissertation Abstracts International, Volume: 68-12, Section: B, page: 8015.
502 $a Thesis (Ph.D.)--Stanford University, 2008.
520 $a In 1967, the field of in vitro evolution was born when Spiegelman and coworkers demonstrated the first "extracellular Darwinian experiment". In vitro evolution strategies are now used routinely to isolated biopolymers with desired functional properties. In more recent years, our lab and others have been interested in applying evolution-based search strategies to synthetic compounds, as doing so could radically simplify small-molecule discovery, with applications in countless fields.
520 $a This thesis first reviews the new "chemical evolution" movement, discussing key advances and future directions of the field. Second, chemical methods for DNA-programmed library synthesis are presented, including the validation of comprehensive strategies for peptide and peptoid synthesis. Third, the chemical strategies are utilized to generate a DNA-programmed library of 100 million novel compounds. The library is subjected to multiple rounds of in vitro selection for protein binding, and it converges to a small number of sequence families, which are validated to represent true synthetic ligands. The work represents the first example of evolution-based discovery of synthetic compounds.
590 $a School code: 0212.
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Chemistry, Organic. $3 516206
690 $a 0487
690 $a 0490
690 $a 0715
710 2 $a Stanford University. $3 754827
773 0 $t Dissertation Abstracts International $g 68-12B.
790 $a 0212
790 1 0 $a Harbury, Pehr B., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3292431