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Lipoprotein(a): Metabolic and ather...

Paultre, Furcy.

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Lipoprotein(a): Metabolic and atherogenic properties.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Lipoprotein(a): Metabolic and atherogenic properties./
Author:	Paultre, Furcy.
Description:	170 p.
Notes:	Advisers: Lars Berglund; Richard Deckelbaum.
Contained By:	Dissertation Abstracts International61-12B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9998199
ISBN:	0493065040

Lipoprotein(a): Metabolic and atherogenic properties.
Paultre, Furcy.

Lipoprotein(a): Metabolic and atherogenic properties. - 170 p.

Advisers: Lars Berglund; Richard Deckelbaum.

Thesis (Ph.D.)--Columbia University, 2001.

This thesis explored two aspects of lipoprotein(a). The first was the role of ethnicity in the association between properties of lipoprotein(a) and atherosclerosis and the second was metabolic properties of lipoprotein(a).

ISBN: 0493065040Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Lipoprotein(a): Metabolic and atherogenic properties.
LDR:02328nam 2200301 a 45 001 938672
005 20110512
008 110512s2001 eng d
020 $a 0493065040
035 $a (UnM)AAI9998199
035 $a AAI9998199
040 $a UnM $c UnM
100 1 $a Paultre, Furcy. $3 1262646
245 1 0 $a Lipoprotein(a): Metabolic and atherogenic properties.
300 $a 170 p.
500 $a Advisers: Lars Berglund; Richard Deckelbaum.
500 $a Source: Dissertation Abstracts International, Volume: 61-12, Section: B, page: 6401.
502 $a Thesis (Ph.D.)--Columbia University, 2001.
520 $a This thesis explored two aspects of lipoprotein(a). The first was the role of ethnicity in the association between properties of lipoprotein(a) and atherosclerosis and the second was metabolic properties of lipoprotein(a).
520 $a A significant association was found between elevated levels of lipoprotein(a) particles with small apo(a) isoforms, in men independent of ethnicity, with coronary artery disease in a case-control study and with carotid atherosclerosis in a random stroke-free population-based sample. These are the first studies demonstrating a significant association between lipoprotein(a) and coronary artery disease in African Americans. These findings suggest that the absence of association between lipoprotein(a) and coronary artery disease in African Americans in previous studies was not due to a difference in the atherogenicity of Lipoprotein(a) across race/ethnicity, but a consequence of race/ethnicity differences in the distribution of lipoprotein(a) levels across apo(a) sizes.
520 $a The metabolic study, which used a primed constant infusion of stable isotopes, demonstrated in six normolipidemic subjects with high lipoprotein(a) levels that low density lipoprotein apoB does not seem to be a major direct precursor for lipoprotein(a) apo B. Furthermore, the data are consistent with the hypothesis that lipoprotein(a) apo B and lipoprotein(a) apo(a) have similar metabolic pathways.
590 $a School code: 0054.
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0570
710 2 0 $a Columbia University. $3 571054
773 0 $t Dissertation Abstracts International $g 61-12B.
790 $a 0054
790 1 0 $a Berglund, Lars, $e advisor
790 1 0 $a Deckelbaum, Richard, $e advisor
791 $a Ph.D.
792 $a 2001
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9998199