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Modularity of pleiotropic effects on...

Washington University in St. Louis.

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Modularity of pleiotropic effects on skeletal morphology.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Modularity of pleiotropic effects on skeletal morphology./
作者:	Kenney-Hunt, Jane P.
面頁冊數:	171 p.
附註:	Adviser: James Cheverud.
Contained By:	Dissertation Abstracts International68-06B.
標題:	Biology, Bioinformatics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3268044
ISBN:	9780549070320

Modularity of pleiotropic effects on skeletal morphology.
Kenney-Hunt, Jane P.

Modularity of pleiotropic effects on skeletal morphology. - 171 p.

Adviser: James Cheverud.

Thesis (Ph.D.)--Washington University in St. Louis, 2007.

In order to understand the role of genetic variation in morphological evolution, it is important to understand the genetic architecture of morphological traits because different genetic architectures can have varied effects on evolutionary responses to selection and genetic drift. Aspects of genetic architecture include number and size of gene effects, dominance, epistasis, and pleiotropy.

ISBN: 9780549070320Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Modularity of pleiotropic effects on skeletal morphology.
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502 $a Thesis (Ph.D.)--Washington University in St. Louis, 2007.
520 $a In order to understand the role of genetic variation in morphological evolution, it is important to understand the genetic architecture of morphological traits because different genetic architectures can have varied effects on evolutionary responses to selection and genetic drift. Aspects of genetic architecture include number and size of gene effects, dominance, epistasis, and pleiotropy.
520 $a Pleiotropy is predicted to evolve so that functionally and developmentally related traits are influenced by specific loci that differ for different functional sets. When aspects of functional systems evolve in concert, adaptive evolution is facilitated. Thus, the evolution of development is predicted to result in a nested hierarchy of gene effects reflecting the nested hierarchy of functional and/or developmental processes. I have undertaken a comprehensive survey of pleiotropic patterns affecting mouse skeletal morphology, using quantitative trait locus (QTL) analysis on seventy traits throughout the skeleton, including aspects of several modules at various levels of morphological hierarchy, in order to elucidate the evolved genetic architecture of skeletal morphology and the consequences of this architecture for evolutionary processes.
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