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The role of vitamin A in late embryo...

The University of Wisconsin - Madison.

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The role of vitamin A in late embryonic development.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The role of vitamin A in late embryonic development./
Author:	See, Angela Wai-Man.
Description:	243 p.
Notes:	Adviser: Margaret Clagett-Dame.
Contained By:	Dissertation Abstracts International69-05B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3314392
ISBN:	9780549637554

The role of vitamin A in late embryonic development.
See, Angela Wai-Man.

The role of vitamin A in late embryonic development. - 243 p.

Adviser: Margaret Clagett-Dame.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2008.

Vitamin A (retinol, ROL) is essential for embryogenesis. Early work showed that complete vitamin A deficiency (VAD) leads to conception failure and partial deficiency results in highly variable outcomes, including fetal resorption and defects in organogenesis. In order to study the role of vitamin A in the later stages of embryogenesis, a nutritional model was developed that produces late VAD in rat fetuses and defects in organogenesis that are fully penetrant. In this model, pregnant VAD animals are supported during early gestation (E0.5 to E8.5) on an adequate level of all- trans retinoic acid (atRA) followed by the feeding of higher atRA to prevent mid-gestational death. Feeding of a lower level of dietary atRA after E10.5 produces a state of late fetal VAD, whereas supplementation with retinol after E10.5 yields normal fetuses. This model takes advantage of the short biological half-life of atRA, and the fact that this metabolite is not stored, thus enabling production of VAD at a precise time in later development. Developmental defects in multiple organs were observed at 100% in the late VAD fetuses, and unique defects in the thoracic, sacral and pelvic regions of the skeleton were also revealed.

ISBN: 9780549637554Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

The role of vitamin A in late embryonic development.
LDR:02992nam 2200277 a 45 001 856944
005 20100709
008 100709s2008 ||||||||||||||||| ||eng d
020 $a 9780549637554
035 $a (UMI)AAI3314392
035 $a AAI3314392
040 $a UMI $c UMI
100 1 $a See, Angela Wai-Man. $3 1023836
245 1 4 $a The role of vitamin A in late embryonic development.
300 $a 243 p.
500 $a Adviser: Margaret Clagett-Dame.
500 $a Source: Dissertation Abstracts International, Volume: 69-05, Section: B, page: 2919.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2008.
520 $a Vitamin A (retinol, ROL) is essential for embryogenesis. Early work showed that complete vitamin A deficiency (VAD) leads to conception failure and partial deficiency results in highly variable outcomes, including fetal resorption and defects in organogenesis. In order to study the role of vitamin A in the later stages of embryogenesis, a nutritional model was developed that produces late VAD in rat fetuses and defects in organogenesis that are fully penetrant. In this model, pregnant VAD animals are supported during early gestation (E0.5 to E8.5) on an adequate level of all- trans retinoic acid (atRA) followed by the feeding of higher atRA to prevent mid-gestational death. Feeding of a lower level of dietary atRA after E10.5 produces a state of late fetal VAD, whereas supplementation with retinol after E10.5 yields normal fetuses. This model takes advantage of the short biological half-life of atRA, and the fact that this metabolite is not stored, thus enabling production of VAD at a precise time in later development. Developmental defects in multiple organs were observed at 100% in the late VAD fetuses, and unique defects in the thoracic, sacral and pelvic regions of the skeleton were also revealed.
520 $a This model was further extended to study the role of vitamin A in eye development at specific times during later development by varying the time when ROL was added back to the diet of late VAD embryos. Eye defects were present in all late VAD fetuses. Addition of ROL by E15.5 failed to rescue any eye anomalies; addition of ROL by E14.5 was able to rescue some of the retrolenticular fibroplasia; addition of ROL by E13.5 enabled complete rescue of retrolenticular fibroplasia as well as retinal folding defects; addition of ROL by E12.5 rescued 83% of the coloboma; and addition of ROL by E11.5 rescued all the eye defects in the late VAD. Using this method, the molecular basis for vitamin A action in eye development was further explored. In summary, this work defines a nutritional approach that can be used to study the role and mechanism of action of vitamin A during fetal development.
590 $a School code: 0262.
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0570
710 2 $a The University of Wisconsin - Madison. $3 626640
773 0 $t Dissertation Abstracts International $g 69-05B.
790 $a 0262
790 1 0 $a Clagett-Dame, Margaret, $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3314392