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Expression evolution of mammalian genes.

University of Michigan.

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Expression evolution of mammalian genes.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Expression evolution of mammalian genes./
作者:	Liao, Ben-Yang.
面頁冊數:	169 p.
附註:	Adviser: Jianzhi Zhang.
Contained By:	Dissertation Abstracts International69-09B.
標題:	Biology, Bioinformatics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3328891
ISBN:	9780549817932

Expression evolution of mammalian genes.
Liao, Ben-Yang.

Expression evolution of mammalian genes. - 169 p.

Adviser: Jianzhi Zhang.

Thesis (Ph.D.)--University of Michigan, 2008.

Comparing the expression-profiles of over 10,000 genes from the human and mouse genomes, I address fundamental questions on mammalian gene expression. First, I demonstrate that over 80% of human-mouse orthologous genes are evolutionarily conserved in their expression-profiles. This result highlights the importance of proper gene expression to fitness. Second, I show that highly expressed and tissue-specific genes tend to evolve slowly in expression-profile, implying that the expression pattern is of particular importance to highly expressed and tissue-specific genes. I then investigate the potential roles that gene expression plays in protein sequence evolution, dynamics of genome organization, and evolutionary changes of gene essentiality in mammals. My results indicate that tissue-specificity is a stronger determinant on protein evolutionary rate than gene expression level, a factor that is known to be the most important rate determinant in yeasts. The result suggests a great variation in rate determinants of protein sequence evolution between unicellular and multicellular organisms. Subsequently, my analyses on the origin of co-expressed gene clusters indicate that co-expression of linked genes is a form of transcriptional interference that is disadvantageous to organisms, suggesting that transcriptional interference may promote recurrent relocations of genes in the genome. Lastly, I study underlying mechanisms of the evolution of gene essentiality. The results show that the changes of gene essentiality appear to be associated with adaptive evolution at the protein-sequence level, while gene duplication and gene expression evolution plays a negligible role. Together, my studies help understand patterns, mechanisms and consequences of gene expression evolution.

ISBN: 9780549817932Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Expression evolution of mammalian genes.
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