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Evolution of fungal transcription ci...

University of California, San Francisco., Biological and Medical Informatics.

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Evolution of fungal transcription circuits.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Evolution of fungal transcription circuits./
Author:	Tuch, Brian B.
Description:	274 p.
Notes:	Advisers: Alexander D. Johnson; Hao Li.
Contained By:	Dissertation Abstracts International69-02B.
Subject:	Biology, Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3297786
ISBN:	9780549487784

Evolution of fungal transcription circuits.
Tuch, Brian B.

Evolution of fungal transcription circuits. - 274 p.

Advisers: Alexander D. Johnson; Hao Li.

Thesis (Ph.D.)--University of California, San Francisco, 2008.

The gradual rewiring of transcriptional circuits over evolutionary timescales is a major source of the diversity of life on the planet. Studies in animals have shown how seemingly small changes in gene regulation can have large effects on morphology and physiology and how selective pressures can act on these changes. The underlying principle in these studies is that gene regulation is modular---changes can be made to the expression of a gene at one place and time, without affecting the expression of that gene at other places and times. Genome-wide studies in single cell yeasts, including those described here, have uncovered evidence of massive transcriptional rewiring, indicating that even closely related species regulate their genes using surprisingly different circuitries. The work described in this thesis begins to suggest some general principles guiding the evolution of transcription circuits. Mechanisms by which large sets of co-expressed genes can be rewired (without disrupting co-expression) are proposed and combinatorial regulation is implicated as a catalyst for change in transcriptional networks.

ISBN: 9780549487784Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Evolution of fungal transcription circuits.
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008 100630s2008 ||||||||||||||||| ||eng d
020 $a 9780549487784
035 $a (UMI)AAI3297786
035 $a AAI3297786
040 $a UMI $c UMI
100 1 $a Tuch, Brian B. $3 1018681
245 1 0 $a Evolution of fungal transcription circuits.
300 $a 274 p.
500 $a Advisers: Alexander D. Johnson; Hao Li.
500 $a Source: Dissertation Abstracts International, Volume: 69-02, Section: B, page: 0761.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2008.
520 $a The gradual rewiring of transcriptional circuits over evolutionary timescales is a major source of the diversity of life on the planet. Studies in animals have shown how seemingly small changes in gene regulation can have large effects on morphology and physiology and how selective pressures can act on these changes. The underlying principle in these studies is that gene regulation is modular---changes can be made to the expression of a gene at one place and time, without affecting the expression of that gene at other places and times. Genome-wide studies in single cell yeasts, including those described here, have uncovered evidence of massive transcriptional rewiring, indicating that even closely related species regulate their genes using surprisingly different circuitries. The work described in this thesis begins to suggest some general principles guiding the evolution of transcription circuits. Mechanisms by which large sets of co-expressed genes can be rewired (without disrupting co-expression) are proposed and combinatorial regulation is implicated as a catalyst for change in transcriptional networks.
590 $a School code: 0034.
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Biology, General. $3 1018625
650 4 $a Biology, Genetics. $3 1017730
690 $a 0306
690 $a 0369
690 $a 0715
710 2 $a University of California, San Francisco. $b Biological and Medical Informatics. $3 1018680
773 0 $t Dissertation Abstracts International $g 69-02B.
790 $a 0034
790 1 0 $a DeRisi, Joseph L. $e committee member
790 1 0 $a Johnson, Alexander D., $e advisor
790 1 0 $a Li, Hao, $e advisor
790 1 0 $a Madhani, Hiten D. $e committee member
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3297786