東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Natural selection on the coding and ...

The University of Chicago.

FindBook

Google Book

Amazon

博客來

Natural selection on the coding and non-coding genes at the genome level.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Natural selection on the coding and non-coding genes at the genome level./
作者:	Lu, Jian.
面頁冊數:	176 p.
附註:	Adviser: Chung-I Wu.
Contained By:	Dissertation Abstracts International69-02B.
標題:	Biology, Bioinformatics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3300439
ISBN:	9780549458296

Natural selection on the coding and non-coding genes at the genome level.
Lu, Jian.

Natural selection on the coding and non-coding genes at the genome level. - 176 p.

Adviser: Chung-I Wu.

Thesis (Ph.D.)--The University of Chicago, 2008.

The nearly neutral theory argued that slightly deleterious mutations can be fixed across the population. If this theory holds true in general, how much of the molecular divergence between closely related species might be contributed by slightly deleterious mutations? What are their consequences? These are the questions I am addressing in my Ph. D thesis. By comparing the evolutionary rates of X chromosome vs. autosomes between human and chimpanzee, I concluded that at least 90% of the synonymous substitutions are deleterious but the fitness effect is very week. By comparing 4,000 orthologous genes across the two subspecies of the domesticated rice, Oryza Sotiva and the wild rice, I estimated that about 25% of the amino acid changes are deleterious but persist in the genoines of domesticated rice.

ISBN: 9780549458296Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Natural selection on the coding and non-coding genes at the genome level.
LDR:02666nam 2200289 a 45 001 852683
005 20100630
008 100630s2008 ||||||||||||||||| ||eng d
020 $a 9780549458296
035 $a (UMI)AAI3300439
035 $a AAI3300439
040 $a UMI $c UMI
100 1 $a Lu, Jian. $3 1018676
245 1 0 $a Natural selection on the coding and non-coding genes at the genome level.
300 $a 176 p.
500 $a Adviser: Chung-I Wu.
500 $a Source: Dissertation Abstracts International, Volume: 69-02, Section: B, page: 0810.
502 $a Thesis (Ph.D.)--The University of Chicago, 2008.
520 $a The nearly neutral theory argued that slightly deleterious mutations can be fixed across the population. If this theory holds true in general, how much of the molecular divergence between closely related species might be contributed by slightly deleterious mutations? What are their consequences? These are the questions I am addressing in my Ph. D thesis. By comparing the evolutionary rates of X chromosome vs. autosomes between human and chimpanzee, I concluded that at least 90% of the synonymous substitutions are deleterious but the fitness effect is very week. By comparing 4,000 orthologous genes across the two subspecies of the domesticated rice, Oryza Sotiva and the wild rice, I estimated that about 25% of the amino acid changes are deleterious but persist in the genoines of domesticated rice.
520 $a Besides the deleterious effects of genetic novelties generated by point mutations, I am also very interested in the possible detrimental effects posed by other kinds of genetic novelties, e.g., the origin of regulatory novelties. The birth of microRNAs belongs in such a class of questions. By deep-sequencing of microRNAs from three species of Drosophila, I observed a large class of miRNA genes that are evolutionarily young. Among them, only 2.4% eventually become functionally integrated into the genome; the remaining 97.6% might be neutral or deleterious to the fitness of the organism, thus this class of microRNAs are not favored/maintained by natural selection and they degenerate very rapidly. By comparing the divergence and polymorphism of 4 newly emerged miRNA genes that have survived in the genome for more than 50 Myrs, we infer that such miRNAs have undergone a long period of adaptive evolution and accumulated many changes before functional integration.
590 $a School code: 0330.
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
690 $a 0715
710 2 $a The University of Chicago. $3 1017389
773 0 $t Dissertation Abstracts International $g 69-02B.
790 $a 0330
790 1 0 $a Wu, Chung-I, $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3300439