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Improvement of Intrapleural Fibrinol...

De Vera, Christian Jordan.

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Improvement of Intrapleural Fibrinolytic Therapy in a Streptococcus pneumoniae-Induced Advanced Empyema Rabbit Model.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Improvement of Intrapleural Fibrinolytic Therapy in a Streptococcus pneumoniae-Induced Advanced Empyema Rabbit Model./
作者:	De Vera, Christian Jordan.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	85 p.
附註:	Source: Masters Abstracts International, Volume: 82-01.
Contained By:	Masters Abstracts International82-01.
標題:	Translation studies. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28024108
ISBN:	9798662411326

Improvement of Intrapleural Fibrinolytic Therapy in a Streptococcus pneumoniae-Induced Advanced Empyema Rabbit Model.
De Vera, Christian Jordan.

Improvement of Intrapleural Fibrinolytic Therapy in a Streptococcus pneumoniae-Induced Advanced Empyema Rabbit Model. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 85 p.

Source: Masters Abstracts International, Volume: 82-01.

Thesis (M.S.)--The University of Texas Health Science Center at Tyler, 2020.

This item is not available from ProQuest Dissertations & Theses.

Empyema is clinically defined as the accumulation of pus in the pleural cavity, as a complication of severe pneumonia. Intrapleural Fibrinolytic Therapy (IPFT) is a low invasive and more economical option for treating empyema. IPFT with single chain (sc) urokinase (uPA) and tissue (tPA) plasminogen activators of advanced Streptococcus pneumoniae-induced empyema in rabbits was studied in order to understand molecular mechanisms of fibrinolysis. The results demonstrate that: (1) the rabbit model recapitulates human empyema, where advanced stage becomes more resistant to IPFT; (2) slow fibrinolysis may require higher bolus doses or multiple injections of plasminogen activators; (3) elevated plasminogen activator inhibitor-1 (PAI-1) remains a molecular target susceptible for IPFT with sctPA and Docking Site Peptide (DSP); (4) Nb42, a nanobody, which interferes with exosite interactions, could be used together with DSP to increase efficacy of PAI-1 targeting. This thesis contributes to a foundation for finding successful treatment for advanced empyema.

ISBN: 9798662411326Subjects--Topical Terms:

3310485
Translation studies.
Subjects--Index Terms:

Biochemistry

Improvement of Intrapleural Fibrinolytic Therapy in a Streptococcus pneumoniae-Induced Advanced Empyema Rabbit Model.
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300 $a 85 p.
500 $a Source: Masters Abstracts International, Volume: 82-01.
500 $a Advisor: Florova, Galina.
502 $a Thesis (M.S.)--The University of Texas Health Science Center at Tyler, 2020.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a Empyema is clinically defined as the accumulation of pus in the pleural cavity, as a complication of severe pneumonia. Intrapleural Fibrinolytic Therapy (IPFT) is a low invasive and more economical option for treating empyema. IPFT with single chain (sc) urokinase (uPA) and tissue (tPA) plasminogen activators of advanced Streptococcus pneumoniae-induced empyema in rabbits was studied in order to understand molecular mechanisms of fibrinolysis. The results demonstrate that: (1) the rabbit model recapitulates human empyema, where advanced stage becomes more resistant to IPFT; (2) slow fibrinolysis may require higher bolus doses or multiple injections of plasminogen activators; (3) elevated plasminogen activator inhibitor-1 (PAI-1) remains a molecular target susceptible for IPFT with sctPA and Docking Site Peptide (DSP); (4) Nb42, a nanobody, which interferes with exosite interactions, could be used together with DSP to increase efficacy of PAI-1 targeting. This thesis contributes to a foundation for finding successful treatment for advanced empyema.
590 $a School code: 1891.
650 4 $a Translation studies. $3 3310485
650 4 $a Molecular biology. $3 517296
650 4 $a Biochemistry. $3 518028
653 $a Biochemistry
653 $a Biology
653 $a Biotechnology
653 $a Translational medicine
690 $a 0213
690 $a 0307
690 $a 0487
710 2 $a The University of Texas Health Science Center at Tyler. $b Cellular and Molecular Biology. $3 3562511
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791 $a M.S.
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