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Dietary advanced glycation end produ...

Duong, Michelle.

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Dietary advanced glycation end products (AGEs) and brain health.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Dietary advanced glycation end products (AGEs) and brain health./
Author:	Duong, Michelle.
Description:	146 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.
Contained By:	Dissertation Abstracts International74-10B(E).
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3567262
ISBN:	9781303190124

Dietary advanced glycation end products (AGEs) and brain health.
Duong, Michelle.

Dietary advanced glycation end products (AGEs) and brain health. - 146 p.

Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.

Thesis (Ph.D.)--New York University, 2013.

Background: The Western diet contains high amounts of dietary advanced glycation end products (AGEs), which have been found to promote insulin resistance, various micro- and macro-vascular diabetic complications, inflammation, oxidative stress, and endothelial dysfunction. In the brain, this endothelial dysfunction may lead to reduced cognition in adults with insulin resistance and T2DM. Methods: This cross-sectional study evaluated the relationship between AGEs in diet and plasma (dietary AGEs, plasma N-carboxymethyllysine (CML), and plasma methylgloxal (MG)), inflammatory and endothelial markers, and resting hippocampal blood flow (rHBF) in 13 healthy controls, 17 insulin resistant and 11 participants with Type 2 Diabetes Mellitus (T2DM). Data were collected using validated methods, including dietary assessment (Block Food Frequency Questionnaire and Mt. Sinai AGE questionnaire), arterial spin labeled MRI (ASL-MRI), and endothelial and inflammatory marker assays. All statistical analyses were adjusted for age, smoking, energy intake, and antioxidant intake. Results: Plasma AGEs significantly correlated to dietary AGEs (CML, r = 0.317, P = 0.063; MG, r = 0.421, P = 0.012). Plasma CML significantly predicted rHBF (beta = -0.43, 95% CI: -204.14, -28). The relationship between CML, MG, and rHBF illustrated the presence of an interaction by levels of glucose control. AGEs in diet and plasma were not significantly associated with inflammation, as measured by endothelial markers vascular cell adhesion molecule (VCAM-1) and vascular endothelial growth factor (VEGF), and inflammatory markers tumor necrosis factor alpha (TNF-alpha) (P > 0.05). Lastly, results from a Sobel mediation analysis did not indicate mediation by inflammation on the relationship between AGEs and rHBF (P > 0.05) Conclusion: In agreement with the current literature, dietary AGEs are correlated to plasma AGEs. Plasma AGEs may predict decline in resting hippocampal blood blow (rHBF), an indication of progression to hippocampal impairment. Moreover, potentially AGE-induced decline in rHBF may be stratified by levels of glucose control, with healthy persons illustrating greater robustness in preservation of rHBF compared to persons with insulin resistance and T2DM. With further confirmation from larger experimental studies, following a low-AGE diet may be beneficial for brain health.

ISBN: 9781303190124Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Dietary advanced glycation end products (AGEs) and brain health.
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008 150210s2013 ||||||||||||||||| ||eng d
020 $a 9781303190124
035 $a (MiAaPQ)AAI3567262
035 $a AAI3567262
040 $a MiAaPQ $c MiAaPQ
100 1 $a Duong, Michelle. $3 2106110
245 1 0 $a Dietary advanced glycation end products (AGEs) and brain health.
300 $a 146 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.
500 $a Adviser: Domingo J. Pinero.
502 $a Thesis (Ph.D.)--New York University, 2013.
520 $a Background: The Western diet contains high amounts of dietary advanced glycation end products (AGEs), which have been found to promote insulin resistance, various micro- and macro-vascular diabetic complications, inflammation, oxidative stress, and endothelial dysfunction. In the brain, this endothelial dysfunction may lead to reduced cognition in adults with insulin resistance and T2DM. Methods: This cross-sectional study evaluated the relationship between AGEs in diet and plasma (dietary AGEs, plasma N-carboxymethyllysine (CML), and plasma methylgloxal (MG)), inflammatory and endothelial markers, and resting hippocampal blood flow (rHBF) in 13 healthy controls, 17 insulin resistant and 11 participants with Type 2 Diabetes Mellitus (T2DM). Data were collected using validated methods, including dietary assessment (Block Food Frequency Questionnaire and Mt. Sinai AGE questionnaire), arterial spin labeled MRI (ASL-MRI), and endothelial and inflammatory marker assays. All statistical analyses were adjusted for age, smoking, energy intake, and antioxidant intake. Results: Plasma AGEs significantly correlated to dietary AGEs (CML, r = 0.317, P = 0.063; MG, r = 0.421, P = 0.012). Plasma CML significantly predicted rHBF (beta = -0.43, 95% CI: -204.14, -28). The relationship between CML, MG, and rHBF illustrated the presence of an interaction by levels of glucose control. AGEs in diet and plasma were not significantly associated with inflammation, as measured by endothelial markers vascular cell adhesion molecule (VCAM-1) and vascular endothelial growth factor (VEGF), and inflammatory markers tumor necrosis factor alpha (TNF-alpha) (P > 0.05). Lastly, results from a Sobel mediation analysis did not indicate mediation by inflammation on the relationship between AGEs and rHBF (P > 0.05) Conclusion: In agreement with the current literature, dietary AGEs are correlated to plasma AGEs. Plasma AGEs may predict decline in resting hippocampal blood blow (rHBF), an indication of progression to hippocampal impairment. Moreover, potentially AGE-induced decline in rHBF may be stratified by levels of glucose control, with healthy persons illustrating greater robustness in preservation of rHBF compared to persons with insulin resistance and T2DM. With further confirmation from larger experimental studies, following a low-AGE diet may be beneficial for brain health.
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650 4 $a Biology, Neuroscience. $3 1017680
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710 2 $a New York University. $b Nutrition, Food Studies, and Public Health. $3 2106111
773 0 $t Dissertation Abstracts International $g 74-10B(E).
790 $a 0146
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3567262