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Modulation of prostate and pancreati...

Warnert, Marissa A.

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Modulation of prostate and pancreatic PhIP-DNA adducts by consumption of cruciferous and apiaceous vegetables in male Wistar rats.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Modulation of prostate and pancreatic PhIP-DNA adducts by consumption of cruciferous and apiaceous vegetables in male Wistar rats./
Author:	Warnert, Marissa A.
Description:	142 p.
Notes:	Source: Masters Abstracts International, Volume: 52-02.
Contained By:	Masters Abstracts International52-02(E).
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1545412
ISBN:	9781303394492

Modulation of prostate and pancreatic PhIP-DNA adducts by consumption of cruciferous and apiaceous vegetables in male Wistar rats.
Warnert, Marissa A.

Modulation of prostate and pancreatic PhIP-DNA adducts by consumption of cruciferous and apiaceous vegetables in male Wistar rats. - 142 p.

Source: Masters Abstracts International, Volume: 52-02.

Thesis (M.S.)--University of Minnesota, 2013.

PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is one of the most abundant heterocylic aromatic amines (HAA), which are dietary procarcinogens in over-cooked meat. Some phase I biotransformation enzymes activate several HAA, including PhIP, while specific phase II enzymes can detoxify PhIP and other HAAs. Cruciferous vegetables induce phase I and phase II enzymes, while apiaceous vegetables inhibit phase I enzymes; but it's unknown if their combined intake acts synergistically on carcinogen metabolism. We evaluated the effects of cruciferous and apiaceous vegetables, and their respective phytochemicals, either alone or combined, on prostate and pancreatic PhIP-DNA adducts in rats. For prostate, PhIP-DNA adducts were reduced by 1-week intake of apiaceous vegetables (by 33%, P < 0.05), PEITC/I3C (by 45%, P < .001), and the combination of PEITC/I3C + furanocoumarins (30% reduction, P < .01). There were no effects in pancreas. Our results suggest fresh vegetables and phytochemicals modulate biotransformation enzymes and may influence cancer risk.

ISBN: 9781303394492Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Modulation of prostate and pancreatic PhIP-DNA adducts by consumption of cruciferous and apiaceous vegetables in male Wistar rats.
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100 1 $a Warnert, Marissa A. $3 2102356
245 1 0 $a Modulation of prostate and pancreatic PhIP-DNA adducts by consumption of cruciferous and apiaceous vegetables in male Wistar rats.
300 $a 142 p.
500 $a Source: Masters Abstracts International, Volume: 52-02.
500 $a Adviser: Sabrina P. Trudo.
502 $a Thesis (M.S.)--University of Minnesota, 2013.
520 $a PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is one of the most abundant heterocylic aromatic amines (HAA), which are dietary procarcinogens in over-cooked meat. Some phase I biotransformation enzymes activate several HAA, including PhIP, while specific phase II enzymes can detoxify PhIP and other HAAs. Cruciferous vegetables induce phase I and phase II enzymes, while apiaceous vegetables inhibit phase I enzymes; but it's unknown if their combined intake acts synergistically on carcinogen metabolism. We evaluated the effects of cruciferous and apiaceous vegetables, and their respective phytochemicals, either alone or combined, on prostate and pancreatic PhIP-DNA adducts in rats. For prostate, PhIP-DNA adducts were reduced by 1-week intake of apiaceous vegetables (by 33%, P < 0.05), PEITC/I3C (by 45%, P < .001), and the combination of PEITC/I3C + furanocoumarins (30% reduction, P < .01). There were no effects in pancreas. Our results suggest fresh vegetables and phytochemicals modulate biotransformation enzymes and may influence cancer risk.
590 $a School code: 0130.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Biology, General. $3 1018625
690 $a 0570
690 $a 0306
710 2 $a University of Minnesota. $b Nutrition. $3 1021837
773 0 $t Masters Abstracts International $g 52-02(E).
790 $a 0130
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1545412