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Leptin and regional bone mass and bo...

Wosje, Karen Sue.

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Leptin and regional bone mass and body composition.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Leptin and regional bone mass and body composition./
Author:	Wosje, Karen Sue.
Description:	185 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2603.
Contained By:	Dissertation Abstracts International64-06B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3097082

Leptin and regional bone mass and body composition.
Wosje, Karen Sue.

Leptin and regional bone mass and body composition. - 185 p.

Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2603.

Thesis (Ph.D.)--South Dakota State University, 2003.

Currently there is no compelling evidence that circulating leptin concentrations predict <italic>regional</italic> body fat distribution. Similarly, previous studies in humans have indicated no or only weak relationships between bone outcomes and circulating leptin. We studied effects of circulating leptin on regional body composition and bone mineral content (BMC) dual energy x-ray absorptiometry (DXA) in 345 Hutterite (n = 264, n = 152 female) and non-Hutterite (n = 81, n = 46 female) individuals ages 20 to 55 years. We tested the following hypotheses: (1) There will be a strong correlation between whole body (WB) percentage (%) fat mass and circulating leptin concentrations. (2) Controlling for covariates, there will be no relationship between trunk percentage fat mass and circulating leptin concentrations. (3) Controlling for covariates, there will be no relationships between WB, lumbar, hip, or regional BMC and circulating leptin concentrations.Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Leptin and regional bone mass and body composition.
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035 $a (UnM)AAI3097082
035 $a AAI3097082
040 $a UnM $c UnM
100 1 $a Wosje, Karen Sue. $3 1945309
245 1 0 $a Leptin and regional bone mass and body composition.
300 $a 185 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2603.
500 $a Adviser: Bonny Specker.
502 $a Thesis (Ph.D.)--South Dakota State University, 2003.
520 $a Currently there is no compelling evidence that circulating leptin concentrations predict <italic>regional</italic> body fat distribution. Similarly, previous studies in humans have indicated no or only weak relationships between bone outcomes and circulating leptin. We studied effects of circulating leptin on regional body composition and bone mineral content (BMC) dual energy x-ray absorptiometry (DXA) in 345 Hutterite (n = 264, n = 152 female) and non-Hutterite (n = 81, n = 46 female) individuals ages 20 to 55 years. We tested the following hypotheses: (1) There will be a strong correlation between whole body (WB) percentage (%) fat mass and circulating leptin concentrations. (2) Controlling for covariates, there will be no relationship between trunk percentage fat mass and circulating leptin concentrations. (3) Controlling for covariates, there will be no relationships between WB, lumbar, hip, or regional BMC and circulating leptin concentrations.
520 $a Using simple linear regression, we observed strong correlations between WB % fat and log-transformed circulating leptin (log-leptin) concentrations among females (R<super>2</super> = 0.74, p ≤ 0.001) and males (R<super> 2</super> = 0.82, p ≤ 0.001). To test hypotheses 2 and 3, we performed stepwise multiple regression separately by sex and controlled for nutrient intakes, physical activity, anthropometrics, grip strength, and estrogen status. Log-leptin persisted in multiple regression models predicting trunk % fat for both females (p ≤ 0.05) and males (p ≤ 0.001).
520 $a In males, relative log-leptin (log-leptin/WB fat mass) was positively associated with trunk % fat among lean {body mass index (BMI) < 25 kg/m<super> 2</super>}, but inversely associated with trunk % fat in obese (BMI ≥ 30 kg/m<super>2</super>) (p ≤ 0.001 for BMI category*relative log-leptin, both models).
520 $a Among females, we found a <italic>positive</italic> independent effect of log-leptin on lumbar spine (p ≤ 0.001) BMC, but a <italic>negative</italic> effect on trunk and arm BMC. Log-leptin did not independently predict any BMC outcomes in males.
520 $a Our data show that a sexual dimorphism exists in the bone response to circulating leptin. Importantly, it is likely that the beneficial effect of obesity on bone density is mediated by leptin in the primarily trabecular, fracture susceptible lumbar site in females. Studies to determine potential confounding effects of sex hormones on leptin's relationship with BMC are essential.
590 $a School code: 0205.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0570
690 $a 0433
710 2 0 $a South Dakota State University. $3 1019395
773 0 $t Dissertation Abstracts International $g 64-06B.
790 1 0 $a Specker, Bonny, $e advisor
790 $a 0205
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3097082