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The role of p53 in base excision repair.

Mehboob, Asad.

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The role of p53 in base excision repair.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The role of p53 in base excision repair./
Author:	Mehboob, Asad.
Description:	65 p.
Notes:	Source: Masters Abstracts International, Volume: 42-06, page: 2171.
Contained By:	Masters Abstracts International42-06.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1420108
ISBN:	049624857X

The role of p53 in base excision repair.
Mehboob, Asad.

The role of p53 in base excision repair. - 65 p.

Source: Masters Abstracts International, Volume: 42-06, page: 2171.

Thesis (M.S.)--Wayne State University, 2004.

Wild-type p53 protein has been shown to stimulate BER in extracts of cells. In terms of BER activity, lower levels of beta-pol through MMS treatment did not hinder activity as much as the protein was affected. Other studies have suggested APE and p53 function as a complex (Offer et al., 2001), yet our data do not support this hypothesis.

ISBN: 049624857XSubjects--Topical Terms:

1017801
Health Sciences, Nutrition.

The role of p53 in base excision repair.
LDR:01639nmm 2200289 4500 001 1847488
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008 130614s2004 eng d
020 $a 049624857X
035 $a (UnM)AAI1420108
035 $a AAI1420108
040 $a UnM $c UnM
100 1 $a Mehboob, Asad. $3 1935531
245 1 4 $a The role of p53 in base excision repair.
300 $a 65 p.
500 $a Source: Masters Abstracts International, Volume: 42-06, page: 2171.
500 $a Adviser: Ahmad R. Heydari.
502 $a Thesis (M.S.)--Wayne State University, 2004.
520 $a Wild-type p53 protein has been shown to stimulate BER in extracts of cells. In terms of BER activity, lower levels of beta-pol through MMS treatment did not hinder activity as much as the protein was affected. Other studies have suggested APE and p53 function as a complex (Offer et al., 2001), yet our data do not support this hypothesis.
520 $a Sensitivity of p53 cells to MMS, suggest that some cancers may be preferentially sensitive to chemotherapeutic base-damaging agents similar to MMS produce damage that is repaired by BER. Studies, along with ours, indicate that p53 is playing a role in BER pathways. Expanding our understanding of p53 involvement in DNA repair seems like a logical step to producing better therapeutic regimens for treatments of various cancers. (Abstract shortened by UMI.)
590 $a School code: 0254.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Biology, Molecular. $3 1017719
690 $a 0570
690 $a 0307
710 2 0 $a Wayne State University. $3 975058
773 0 $t Masters Abstracts International $g 42-06.
790 1 0 $a Heydari, Ahmad R., $e advisor
790 $a 0254
791 $a M.S.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1420108