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The growth-suppressive effects of fa...

Bravo, Lou.

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The growth-suppressive effects of farnesol, gamma-tocotrienol, genistein, lovastatin and pomegranate extracts individually and in combinations on human prostate tumor cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The growth-suppressive effects of farnesol, gamma-tocotrienol, genistein, lovastatin and pomegranate extracts individually and in combinations on human prostate tumor cells./
Author:	Bravo, Lou.
Description:	71 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-11, Section: B, page: 5455.
Contained By:	Dissertation Abstracts International64-11B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3114311
ISBN:	0496618045

The growth-suppressive effects of farnesol, gamma-tocotrienol, genistein, lovastatin and pomegranate extracts individually and in combinations on human prostate tumor cells.
Bravo, Lou.

The growth-suppressive effects of farnesol, gamma-tocotrienol, genistein, lovastatin and pomegranate extracts individually and in combinations on human prostate tumor cells. - 71 p.

Source: Dissertation Abstracts International, Volume: 64-11, Section: B, page: 5455.

Thesis (Ph.D.)--Texas Woman's University, 2003.

Epidemiological studies indicate that a plant-based diet is associated with reduced cancer risk. The purpose of this research was to study the anti-tumor effects of farnesol, gamma-tocotrienol, genistein, pomegranate extracts W (fermented pomegranate juice) and P (pomegranate peel) and the drug lovastatin on the proliferation of human DU145 and LNCaP prostate carcinoma cells and PC-3 prostate adenocarcinoma cells. These study agents except lovastatin are readily available in fruits and vegetables.

ISBN: 0496618045Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

The growth-suppressive effects of farnesol, gamma-tocotrienol, genistein, lovastatin and pomegranate extracts individually and in combinations on human prostate tumor cells.
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245 1 4 $a The growth-suppressive effects of farnesol, gamma-tocotrienol, genistein, lovastatin and pomegranate extracts individually and in combinations on human prostate tumor cells.
300 $a 71 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-11, Section: B, page: 5455.
500 $a Adviser: Andie Hsueh.
502 $a Thesis (Ph.D.)--Texas Woman's University, 2003.
520 $a Epidemiological studies indicate that a plant-based diet is associated with reduced cancer risk. The purpose of this research was to study the anti-tumor effects of farnesol, gamma-tocotrienol, genistein, pomegranate extracts W (fermented pomegranate juice) and P (pomegranate peel) and the drug lovastatin on the proliferation of human DU145 and LNCaP prostate carcinoma cells and PC-3 prostate adenocarcinoma cells. These study agents except lovastatin are readily available in fruits and vegetables.
520 $a Farnesol, gamma-tocotrienol, genistein, W, P and lovastatin individually induced a dose-dependent suppression of the proliferation of human DU145 and PC-3 prostate carcinoma cells. Farnesol and genistein also induced a dose-dependent suppression of the proliferation of human LNCaP prostate carcinoma cells. Two-agent blends of genistein and gamma-tocotrienol, lovastatin and gamma-tocotrienol, and extracts W and P suppressed the growth of DU145 cells to a greater extent than the sum of their individual actions, suggesting synergy. Lovastatin at 16 muM inhibited DU145 cell growth by 18%. A two-agent blend of 4 muM lovastatin (4% growth inhibition) and 5 muM gamma-tocotrienol (15% growth inhibition) inhibited cell growth by 54%, which is greater than the sum (19%) of their individual inhibitions and three times the growth inhibition (18%) achieved with 16 muM of lovastatin. A three-agent blend of genistein, gamma-tocotrienol and lovastatin inhibited PC-3 cells by 83% while the sum of their individual actions totaled a 59% inhibition, again suggesting synergy in their interactions. The concentration (1.5 muM) of the lovastatin in the three-agent blend was half the concentration (3 muM) of lovastatin that individually inhibited the growth of the PC-3 cells by a lesser 75%. Genistein and gamma-tocotrienol acting synergistically with lovastatin may lower the drug's effective dose thereby attenuating its associated toxicity. Lowering the effective dose of lovastatin while enhancing its chemotherapeutic potential presents a unique and innovative application to cancer chemotherapy. Additional research is needed to determine how the compounds of this study will affect the normal human prostate cells.
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650 4 $a Biology, Cell. $3 1017686
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Health Sciences, Pharmacology. $3 1017717
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