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Causes and consequences of vitamin B...

Campbell, Alison Karla Lemon.

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Causes and consequences of vitamin B-12 deficiency in Californian Latino elderly.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Causes and consequences of vitamin B-12 deficiency in Californian Latino elderly./
Author:	Campbell, Alison Karla Lemon.
Description:	140 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0661.
Contained By:	Dissertation Abstracts International65-02B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3120968
ISBN:	0496683233

Causes and consequences of vitamin B-12 deficiency in Californian Latino elderly.
Campbell, Alison Karla Lemon.

Causes and consequences of vitamin B-12 deficiency in Californian Latino elderly. - 140 p.

Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0661.

Thesis (Ph.D.)--University of California, Davis, 2003.

The prevalence of vitamin B-12 deficiency among the elderly is high compared to the prevalence of low intake and pernicious anemia. Vitamin B-12 deficiency has been associated with neurological and cognitive impairment. This research investigated predictors of vitamin B-12 status, the effect of a vitamin B-12 intervention on B-12 status and functional indicators, and vitamin B-12 and folate deficiency as predictors of cognitive impairment in the Sacramento Area Latino Study on Aging (SALSA).

ISBN: 0496683233Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Causes and consequences of vitamin B-12 deficiency in Californian Latino elderly.
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100 1 $a Campbell, Alison Karla Lemon. $3 1925279
245 1 0 $a Causes and consequences of vitamin B-12 deficiency in Californian Latino elderly.
300 $a 140 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0661.
500 $a Adviser: Lindsay H. Allen.
502 $a Thesis (Ph.D.)--University of California, Davis, 2003.
520 $a The prevalence of vitamin B-12 deficiency among the elderly is high compared to the prevalence of low intake and pernicious anemia. Vitamin B-12 deficiency has been associated with neurological and cognitive impairment. This research investigated predictors of vitamin B-12 status, the effect of a vitamin B-12 intervention on B-12 status and functional indicators, and vitamin B-12 and folate deficiency as predictors of cognitive impairment in the Sacramento Area Latino Study on Aging (SALSA).
520 $a A sub-set of 57 individuals with low plasma B-12 (<148 pmol/L) was compared with 68 who had marginal plasma B-12 (148--221 pmol/L) and 52 with normal plasma 1312 (>221 pmol/L). Elevated serum gastrin was highly prevalent and was a significant predictor of low plasma B-12 and high plasma homocysteine. Median total B-12 intake exceeded recommendations, and was similar among status groups. Crystalline B-12 intake in the normal B-12 group was higher than in the low B-12 group (p < 0.01), and slightly higher than marginal group (p = 0.07). When serum gastrin was elevated, plasma B-12 was predicted by crystalline B-12, but not intake of B-12 from food.
520 $a A subset (n = 47) of the SALSA population with marginal vitamin B-12 status (plasma B-12 = 148--221 pmol/L) completed a 1 y double-blind supplementation trial with 1 mg/d B-12 or placebo. B-12 supplementation normalized plasma B-12 and MMA in all subjects and Hcy in 21/22. B-12 supplementation did not improve global cognitive function, delayed recall, depression scores, neuropathy or Activities of Daily Living, but there was indication that B-12 may be protective against cognitive decline.
520 $a Plasma B-12, erythrocyte folate, MMA, and homocysteine were evaluated as predictors of cognitive function. Low erythrocyte folate was related to dementia and cognitive impairment, but plasma B-12, MMA, Hey and prevalence of abnormal values were not significantly different among the cognitive function classes.
520 $a We conclude that food-bound B-12 malabsorption is common in this population and could be treated with higher intakes of crystalline B-12. Supplementation with B-12 corrected biochemical abnormalities due to deficiency but did not improve cognitive function. Folate status, but not B-12 status, was a significant predictor of dementia and cognitive impairment in this study.
590 $a School code: 0029.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Health Sciences, Public Health. $3 1017659
690 $a 0570
690 $a 0573
710 2 0 $a University of California, Davis. $3 1018682
773 0 $t Dissertation Abstracts International $g 65-02B.
790 1 0 $a Allen, Lindsay H., $e advisor
790 $a 0029
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3120968