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Analysis and applications of quantit...

Pincus, Zachary S.

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Analysis and applications of quantitative representations of cell morphology.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Analysis and applications of quantitative representations of cell morphology./
作者:	Pincus, Zachary S.
面頁冊數:	110 p.
附註:	Source: Dissertation Abstracts International, Volume: 68-06, Section: B, page: 3484.
Contained By:	Dissertation Abstracts International68-06B.
標題:	Biology, Bioinformatics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3267602
ISBN:	9780549062738

Analysis and applications of quantitative representations of cell morphology.
Pincus, Zachary S.

Analysis and applications of quantitative representations of cell morphology. - 110 p.

Source: Dissertation Abstracts International, Volume: 68-06, Section: B, page: 3484.

Thesis (Ph.D.)--Stanford University, 2007.

Morphology is an important, large-scale manifestation of the global state of cells, and is commonly used as a qualitative or quantitative measure of the outcome of various assays. Herein I describe methods for the numerical representation of cell shape, an analysis of the utility of several different cell-shape representations, statistical methods for comparing cell populations of different shapes, and an approach to using statistical models of shape for finding cells in micrographs. In this work, I have found that principal components analysis of shapes represented as geometric outlines provides measures of morphology which are quantitative, biologically meaningful, human interpretable, and work well across a range of cell types and parameter settings. This representation underlies a suite of software tools that I have developed to facilitate shape representation, comparison, visualization, and analysis.

ISBN: 9780549062738Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Analysis and applications of quantitative representations of cell morphology.
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