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Mechanisms controlling iron mobiliza...

Han, Jian.

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Mechanisms controlling iron mobilization during iron deficiency in rat brain.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mechanisms controlling iron mobilization during iron deficiency in rat brain./
Author:	Han, Jian.
Description:	217 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5081.
Contained By:	Dissertation Abstracts International65-10B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3152181
ISBN:	9780496123339

Mechanisms controlling iron mobilization during iron deficiency in rat brain.
Han, Jian.

Mechanisms controlling iron mobilization during iron deficiency in rat brain. - 217 p.

Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5081.

Thesis (Ph.D.)--The Pennsylvania State University, 2001.

The effect of iron deficiency on brain iron metabolism has not yet been thoroughly studied. A number of investigators have shown that iron and iron-related proteins (ferritin, transferrin, and transferrin receptor) are not uniformly distributed in the brain. As shown in various research models, iron deficiency changes the distribution of various iron-related proteins to different extents. While the iron-related protein responses to iron deficiency have been described, the mRNA expression of these proteins in the brain has not been determined. The present studies were conducted to investigate the mRNA expression of iron-related proteins in the rodent brain and to elucidate the possible mechanisms underlying iron mobilization by these proteins during iron deficiency. The overall hypothesis is that iron deficiency induces changes in brain iron, iron-related proteins and their mRNA and that these changes are heterogeneously distributed across brain regions. These responses describe the adaptive mechanisms in place in the brain when experiencing dietary iron deprivation.

ISBN: 9780496123339Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Mechanisms controlling iron mobilization during iron deficiency in rat brain.
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020 $a 9780496123339
035 $a (UMI)AAI3152181
035 $a AAI3152181
040 $a UMI $c UMI
100 1 $a Han, Jian. $3 1924253
245 1 0 $a Mechanisms controlling iron mobilization during iron deficiency in rat brain.
300 $a 217 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5081.
500 $a Chair: John L. Beard.
502 $a Thesis (Ph.D.)--The Pennsylvania State University, 2001.
520 $a The effect of iron deficiency on brain iron metabolism has not yet been thoroughly studied. A number of investigators have shown that iron and iron-related proteins (ferritin, transferrin, and transferrin receptor) are not uniformly distributed in the brain. As shown in various research models, iron deficiency changes the distribution of various iron-related proteins to different extents. While the iron-related protein responses to iron deficiency have been described, the mRNA expression of these proteins in the brain has not been determined. The present studies were conducted to investigate the mRNA expression of iron-related proteins in the rodent brain and to elucidate the possible mechanisms underlying iron mobilization by these proteins during iron deficiency. The overall hypothesis is that iron deficiency induces changes in brain iron, iron-related proteins and their mRNA and that these changes are heterogeneously distributed across brain regions. These responses describe the adaptive mechanisms in place in the brain when experiencing dietary iron deprivation.
520 $a The first objective was to test the hypothesis that dietary iron deficiency affects the mRNA content of H and L ferritin in rat brain regions (i.e., hippocampus, substantia nigra, striatum, pons, cerebellum, cortex, and thalamus) which subsequently affects the content of H and L ferritin subunit proteins. Results showed that the H to L ferritin mRNA ratio was 6:1. The ratio was not affected by dietary iron deficiency in contrast to a different effect of iron deficiency on liver ferritin mRNA.
520 $a The second objective of this research was to test the hypothesis that iron deficiency affects transferrin, transferrin receptor protein, and their mRNA contents in rat brain regions. The iron-deficient diet significantly decreased brain iron concentration (22%--63%) and increased transferrin concentration (22% to 130%) in a regional specific fashion.
520 $a The third objective was to test the hypothesis that iron-related proteins and their mRNA are expressed in the same type of cells in both control and iron-deficient rat brains. The cellular distribution of iron, H and L ferritin, transferring, and transferrin receptor protein was determined by peroxidase anti-peroxidase immunohistochemistry. (Abstract shortened by UMI.)
590 $a School code: 0176.
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0570
710 2 0 $a The Pennsylvania State University. $3 699896
773 0 $t Dissertation Abstracts International $g 65-10B.
790 1 0 $a Beard, John L., $e advisor
790 $a 0176
791 $a Ph.D.
792 $a 2001
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3152181