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Genistein reduces production of proi...

Hooshmand, Shirin.

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Genistein reduces production of proinflammatory molecules in human chondrocytes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Genistein reduces production of proinflammatory molecules in human chondrocytes./
作者:	Hooshmand, Shirin.
面頁冊數:	57 p.
附註:	Source: Masters Abstracts International, Volume: 44-05, page: 2282.
Contained By:	Masters Abstracts International44-05.
標題:	Health Sciences, Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1433612
ISBN:	9780542601613

Genistein reduces production of proinflammatory molecules in human chondrocytes.
Hooshmand, Shirin.

Genistein reduces production of proinflammatory molecules in human chondrocytes. - 57 p.

Source: Masters Abstracts International, Volume: 44-05, page: 2282.

Thesis (M.S.)--Oklahoma State University, 2006.

Previously, we reported that cartilage is an estrogen receptor (ER) positive tissue and that mRNA levels of ERbeta increase in postmenopausal women with osteoarthritis. Based on our findings and those of other investigators, we hypothesized that local rather than circulating estrogen levels negatively affect chondrocyte metabolism and that selective estrogen receptor modulators (SERM) augment cartilage health. To test the latter part of our hypothesis, we explored the role of genistein, a naturally occurring SERM with high affinity to bind ERbeta, in inhibiting the lipopolysaccharide (LPS)-stimulated cyclooxygenase (COX)-2 but not COX-1 in human chondrocytes (HCH). Cells (PromoCell, Germany) were treated with three levels of genistein (0, 50, and 100 muM). After one hour, the genistein-treated cells were stimulated by one mug/mL LPS for six hours. Cells were then harvested and the cytosolic fraction was isolated for assessing COX-1 and COX-2 protein levels using Western blot technique. Nitric oxide (NO), interleukin-I Beta (IL-1beta), and YKL-40 productions were also measured in cell culture supernatants. (Abstract shortened by UMI.)

ISBN: 9780542601613Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Genistein reduces production of proinflammatory molecules in human chondrocytes.
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502 $a Thesis (M.S.)--Oklahoma State University, 2006.
520 $a Previously, we reported that cartilage is an estrogen receptor (ER) positive tissue and that mRNA levels of ERbeta increase in postmenopausal women with osteoarthritis. Based on our findings and those of other investigators, we hypothesized that local rather than circulating estrogen levels negatively affect chondrocyte metabolism and that selective estrogen receptor modulators (SERM) augment cartilage health. To test the latter part of our hypothesis, we explored the role of genistein, a naturally occurring SERM with high affinity to bind ERbeta, in inhibiting the lipopolysaccharide (LPS)-stimulated cyclooxygenase (COX)-2 but not COX-1 in human chondrocytes (HCH). Cells (PromoCell, Germany) were treated with three levels of genistein (0, 50, and 100 muM). After one hour, the genistein-treated cells were stimulated by one mug/mL LPS for six hours. Cells were then harvested and the cytosolic fraction was isolated for assessing COX-1 and COX-2 protein levels using Western blot technique. Nitric oxide (NO), interleukin-I Beta (IL-1beta), and YKL-40 productions were also measured in cell culture supernatants. (Abstract shortened by UMI.)
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