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The effects of omega-3 fatty acid-en...

Siu, Elizabeth Colavito.

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The effects of omega-3 fatty acid-enriched fish on C-reactive protein levels in postmenopausal women.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effects of omega-3 fatty acid-enriched fish on C-reactive protein levels in postmenopausal women./
Author:	Siu, Elizabeth Colavito.
Description:	215 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3070.
Contained By:	Dissertation Abstracts International66-06B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3180794
ISBN:	9780542208577

The effects of omega-3 fatty acid-enriched fish on C-reactive protein levels in postmenopausal women.
Siu, Elizabeth Colavito.

The effects of omega-3 fatty acid-enriched fish on C-reactive protein levels in postmenopausal women. - 215 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3070.

Thesis (Ph.D.)--The University of Texas School of Public Health, 2005.

Coronary heart disease (CHD) is the leading cause of death in women and rates markedly increase among women after 65 years of age. C-reactive protein (CRP) is a new clinical indicator of atherosclerotic-related inflammation with a direct pathogenic role. Studies show lifestyle factors can modulate CRP. Omega-3 fatty acids have anti-inflammatory properties and studies suggest that eating fish high in omega-3 fatty acids may lower CHD risk in women. This study sought to assess the possible role of omega-3 fatty acids in the reduction of CHD-related inflammation by investigating the effect of fish consumption on CRP levels. Methods. Twenty-four healthy postmenopausal women were randomly assigned to a fish group (usual diet plus two servings per week of enriched fish) or control group (usual diet with no fatty fish) for eight weeks. Omega-3 fatty acid-enriched fish developed by the West Virginia University Aquaculture Division was used. Serum CRP, serum interleukin-6 (IL-6), and the fatty acid content of red blood cells (RBC) were measured before and after the study. Women also completed food records. RESULTS: Baseline levels of CRP were low (85% of the fish group had normal levels) and few changes in CRP risk category were observed. Mean IL-6 levels were reduced by 27% and 35% in the fish and control groups, respectively (p for between-group difference = 0.60). Changes in RBC fatty acid composition were not statistically significant. Compared to control women, women in the fish group had greater reductions in mean triglycerides (p = 0.08), total cholesterol (P = 0.04), and LDL cholesterol levels (p = 0.06). Baseline dietary intake of total and monounsaturated fatty acids tended to be positively associated with baseline CRP, while vitamin E intake was inversely related. Saturated fat intake tended to have a positive association with IL-6. Conclusions. Findings regarding the effect of two servings of fish on CRP and IL-6 levels are inconclusive due to low baseline levels of CRP and IL-6. However, results indicate two servings of fatty fish have favorable effects on blood lipids. The relationship of dietary components with CRP and IL-6 is complex and further research is needed to determine the varying roles of diet on the inflammatory process.

ISBN: 9780542208577Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

The effects of omega-3 fatty acid-enriched fish on C-reactive protein levels in postmenopausal women.
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100 1 $a Siu, Elizabeth Colavito. $3 1913059
245 1 4 $a The effects of omega-3 fatty acid-enriched fish on C-reactive protein levels in postmenopausal women.
300 $a 215 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3070.
500 $a Adviser: R. Sue Day.
502 $a Thesis (Ph.D.)--The University of Texas School of Public Health, 2005.
520 $a Coronary heart disease (CHD) is the leading cause of death in women and rates markedly increase among women after 65 years of age. C-reactive protein (CRP) is a new clinical indicator of atherosclerotic-related inflammation with a direct pathogenic role. Studies show lifestyle factors can modulate CRP. Omega-3 fatty acids have anti-inflammatory properties and studies suggest that eating fish high in omega-3 fatty acids may lower CHD risk in women. This study sought to assess the possible role of omega-3 fatty acids in the reduction of CHD-related inflammation by investigating the effect of fish consumption on CRP levels. Methods. Twenty-four healthy postmenopausal women were randomly assigned to a fish group (usual diet plus two servings per week of enriched fish) or control group (usual diet with no fatty fish) for eight weeks. Omega-3 fatty acid-enriched fish developed by the West Virginia University Aquaculture Division was used. Serum CRP, serum interleukin-6 (IL-6), and the fatty acid content of red blood cells (RBC) were measured before and after the study. Women also completed food records. RESULTS: Baseline levels of CRP were low (85% of the fish group had normal levels) and few changes in CRP risk category were observed. Mean IL-6 levels were reduced by 27% and 35% in the fish and control groups, respectively (p for between-group difference = 0.60). Changes in RBC fatty acid composition were not statistically significant. Compared to control women, women in the fish group had greater reductions in mean triglycerides (p = 0.08), total cholesterol (P = 0.04), and LDL cholesterol levels (p = 0.06). Baseline dietary intake of total and monounsaturated fatty acids tended to be positively associated with baseline CRP, while vitamin E intake was inversely related. Saturated fat intake tended to have a positive association with IL-6. Conclusions. Findings regarding the effect of two servings of fish on CRP and IL-6 levels are inconclusive due to low baseline levels of CRP and IL-6. However, results indicate two servings of fatty fish have favorable effects on blood lipids. The relationship of dietary components with CRP and IL-6 is complex and further research is needed to determine the varying roles of diet on the inflammatory process.
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710 2 0 $a The University of Texas School of Public Health. $3 1023950
773 0 $t Dissertation Abstracts International $g 66-06B.
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