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Tea catechins: Epimerization, antiox...

Xu, Jinze.

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Tea catechins: Epimerization, antioxidant activity and effect on body fatness in rats.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Tea catechins: Epimerization, antioxidant activity and effect on body fatness in rats./
Author:	Xu, Jinze.
Description:	182 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0212.
Contained By:	Dissertation Abstracts International66-01B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3162596
ISBN:	049696481X

Tea catechins: Epimerization, antioxidant activity and effect on body fatness in rats.
Xu, Jinze.

Tea catechins: Epimerization, antioxidant activity and effect on body fatness in rats. - 182 p.

Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0212.

Thesis (Ph.D.)--The Chinese University of Hong Kong (People's Republic of China), 2004.

Green tea contains about 10% tea catechins mainly including (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG). Tea catechins have been shown to be hypocholesterolemic, anticarcinogenic, antioxidative and antibacterial. Recently, canned and bottled tea drinks are getting popular worldwide. However, HPLC analysis revealed that canned and bottled tea drinks were relatively low in tea catechins but they were abundant in catechin epimers, namely (-)-catechin (C), (-)-gallocatechin (GC), (-)-catechin gallate (CG) and (-)-gallocatechin gallate (GCG). In the present study, the epimerization of tea catechins as well as their antioxidant potency, absorption pattern, metabolites and anti-obesity property were investigated.

ISBN: 049696481XSubjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Tea catechins: Epimerization, antioxidant activity and effect on body fatness in rats.
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035 $a (UnM)AAI3162596
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100 1 $a Xu, Jinze. $3 1907507
245 1 0 $a Tea catechins: Epimerization, antioxidant activity and effect on body fatness in rats.
300 $a 182 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0212.
500 $a Adviser: Zhenyu Chen.
502 $a Thesis (Ph.D.)--The Chinese University of Hong Kong (People's Republic of China), 2004.
520 $a Green tea contains about 10% tea catechins mainly including (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG). Tea catechins have been shown to be hypocholesterolemic, anticarcinogenic, antioxidative and antibacterial. Recently, canned and bottled tea drinks are getting popular worldwide. However, HPLC analysis revealed that canned and bottled tea drinks were relatively low in tea catechins but they were abundant in catechin epimers, namely (-)-catechin (C), (-)-gallocatechin (GC), (-)-catechin gallate (CG) and (-)-gallocatechin gallate (GCG). In the present study, the epimerization of tea catechins as well as their antioxidant potency, absorption pattern, metabolites and anti-obesity property were investigated.
520 $a To compare the biological activity of these epimers with their precursors, four tea catechins and four epimers were isolated from Longjing tea infusion. Isolation and purification of each tea catechin and epimer were accomplished by various column chromatographic and semi-preparative HPLC techniques. The antioxidant activity of each epimer with its corresponding tea catechin precursor was conducted in the three in vitro systems, namely human low-density lipoprotein (LDL) oxidation, ferric reducing-antioxidant power (FRAP), and anti-DPPH free radical assays. It was concluded that epimerization reaction occurred in manufacturing canned and bottled tea drinks would not affect significantly antioxidant activity and absorption of total tea polyphenols.
520 $a The anti-obesity effect of tea extract was studied in Sprague-Dawley rats. The results clearly demonstrated that anti-obesity effects of tea catechins (containing 8% EGC, 7% EC, 68% EGCG and 12% ECG of total tea catechins) on rats were dose dependent. The consumption of 200 mg/kg body weight of tea catechins efficiently decreased the body weight as well as weight of total fat pads (sum of epididymal, inguinal and perirenal fats) compared with the control group. It was also found that tea catechins were efficient in reducing body weight and the weight of adipose tissue in both male and female rats. (Abstract shortened by UMI.)
590 $a School code: 1307.
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0570
710 2 0 $a The Chinese University of Hong Kong (People's Republic of China). $3 1265600
773 0 $t Dissertation Abstracts International $g 66-01B.
790 1 0 $a Chen, Zhenyu, $e advisor
790 $a 1307
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3162596