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The effect of folate deficiency on b...

Abdalla, Hala.

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The effect of folate deficiency on base excision repair capacity.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effect of folate deficiency on base excision repair capacity./
Author:	Abdalla, Hala.
Description:	64 p.
Notes:	Source: Masters Abstracts International, Volume: 43-03, page: 0824.
Contained By:	Masters Abstracts International43-03.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1423647
ISBN:	0496115197

The effect of folate deficiency on base excision repair capacity.
Abdalla, Hala.

The effect of folate deficiency on base excision repair capacity. - 64 p.

Source: Masters Abstracts International, Volume: 43-03, page: 0824.

Thesis (M.S.)--Wayne State University, 2004.

The aim of this study was to examine the effect of folate deficiency on the base excision repair (BER) capacity, the pathway responsible for removing damaged. A total of 20 young (3--4 months of age) male C57BL/6 specific pathogen-free mice were divided into two equal groups and fed AIN93G purified isoenergetic diets containing either 0mg/kg folic acid diet (the experimental group) or 2mg/kg folic acid diet (the control group) with 1% succinylsulphathiazole added to all diets for eight weeks. The inability to induce BER activity due to the effect of folate deficiency on p53 or due to other mechanism is important in understanding the mechanism by which folate deficiency increases risk of cancer. This supports the suggestion that folate deficiency inhibits DNA repair. In addition, the initiation of the BER pathway without the completion of the damage repair pathway could result in an accumulation of DNA damages that lead to chromosomal and genetic instability leading to cancer. (Abstract shortened by UMI.)

ISBN: 0496115197Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

The effect of folate deficiency on base excision repair capacity.
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100 1 $a Abdalla, Hala. $3 1905194
245 1 4 $a The effect of folate deficiency on base excision repair capacity.
300 $a 64 p.
500 $a Source: Masters Abstracts International, Volume: 43-03, page: 0824.
500 $a Adviser: Ahmad R. Heydari.
502 $a Thesis (M.S.)--Wayne State University, 2004.
520 $a The aim of this study was to examine the effect of folate deficiency on the base excision repair (BER) capacity, the pathway responsible for removing damaged. A total of 20 young (3--4 months of age) male C57BL/6 specific pathogen-free mice were divided into two equal groups and fed AIN93G purified isoenergetic diets containing either 0mg/kg folic acid diet (the experimental group) or 2mg/kg folic acid diet (the control group) with 1% succinylsulphathiazole added to all diets for eight weeks. The inability to induce BER activity due to the effect of folate deficiency on p53 or due to other mechanism is important in understanding the mechanism by which folate deficiency increases risk of cancer. This supports the suggestion that folate deficiency inhibits DNA repair. In addition, the initiation of the BER pathway without the completion of the damage repair pathway could result in an accumulation of DNA damages that lead to chromosomal and genetic instability leading to cancer. (Abstract shortened by UMI.)
590 $a School code: 0254.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Chemistry, Biochemistry. $3 1017722
690 $a 0570
690 $a 0487
710 2 0 $a Wayne State University. $3 975058
773 0 $t Masters Abstracts International $g 43-03.
790 1 0 $a Heydari, Ahmad R., $e advisor
790 $a 0254
791 $a M.S.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1423647