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Effects of chronic ethanol feeding o...

Chavez Lazo, Pollyanna R. G.

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Effects of chronic ethanol feeding on chemical hepatocarcinogenesis and retinoid metabolism.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effects of chronic ethanol feeding on chemical hepatocarcinogenesis and retinoid metabolism./
Author:	Chavez Lazo, Pollyanna R. G.
Description:	126 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2519.
Contained By:	Dissertation Abstracts International66-05B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3176444
ISBN:	0542155303

Effects of chronic ethanol feeding on chemical hepatocarcinogenesis and retinoid metabolism.
Chavez Lazo, Pollyanna R. G.

Effects of chronic ethanol feeding on chemical hepatocarcinogenesis and retinoid metabolism. - 126 p.

Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2519.

Thesis (Ph.D.)--Tufts University, 2005.

Chronic and excessive alcohol consumption is a significant risk factor for liver cancer and it is known to interfere with retinoid metabolism. Even though ethanol is not a carcinogen by itself, its role as a possible promoter in the carcinogenesis process has been suggested by several experimental investigations. However, due to the complex effects and interactions of ethanol in a biological system, it has been difficult to demonstrate the promoting role of ethanol in a chemical carcinogenesis process. A lack of in vivo evidence, where ethanol could be observed as acting as a promoter of hepatocarcinogenesis, motivated the present thesis work.

ISBN: 0542155303Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Effects of chronic ethanol feeding on chemical hepatocarcinogenesis and retinoid metabolism.
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100 1 $a Chavez Lazo, Pollyanna R. G. $3 1905109
245 1 0 $a Effects of chronic ethanol feeding on chemical hepatocarcinogenesis and retinoid metabolism.
300 $a 126 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2519.
500 $a Adviser: Xiang-Dong Wang.
502 $a Thesis (Ph.D.)--Tufts University, 2005.
520 $a Chronic and excessive alcohol consumption is a significant risk factor for liver cancer and it is known to interfere with retinoid metabolism. Even though ethanol is not a carcinogen by itself, its role as a possible promoter in the carcinogenesis process has been suggested by several experimental investigations. However, due to the complex effects and interactions of ethanol in a biological system, it has been difficult to demonstrate the promoting role of ethanol in a chemical carcinogenesis process. A lack of in vivo evidence, where ethanol could be observed as acting as a promoter of hepatocarcinogenesis, motivated the present thesis work.
520 $a This research investigated whether chronic and excessive ethanol treatment can act as a possible promoter for hepatic carcinogenesis in a diethylnitrosamine initiated animal model, by studying the role of cell proliferation and apoptosis. We observed in the ethanol fed groups lower number of altered hepatic foci as well as lower protein levels of hepatic Cyclin D1 and lower hepatocyte proliferation labeling. This would create an adequate environment for the selection of foci with a resistant phenotype that will eventually evolve into neoplastic lesions.
520 $a In this thesis research we also found higher concentrations of hepatic retinoic acid (RA) and retinol levels in the ethanol fed rats compared to the non-ethanol fed rats, which could suggest in this model a role of ethanol in the biosynthesis of RA with accumulation of retinol.
590 $a School code: 0234.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Health Sciences, Toxicology. $3 1017752
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710 2 0 $a Tufts University. $3 1017847
773 0 $t Dissertation Abstracts International $g 66-05B.
790 1 0 $a Wang, Xiang-Dong, $e advisor
790 $a 0234
791 $a Ph.D.
792 $a 2005
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