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Sex differences in the relationship ...

Anderson, Jennifer S.

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Sex differences in the relationship of polyunsaturated fatty acids and noninvasive imaging measures of subclinical cardiovascular disease.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Sex differences in the relationship of polyunsaturated fatty acids and noninvasive imaging measures of subclinical cardiovascular disease./
Author:	Anderson, Jennifer S.
Description:	93 p.
Notes:	Source: Masters Abstracts International, Volume: 49-06, page: .
Contained By:	Masters Abstracts International49-06.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1494542
ISBN:	9781124695099

Sex differences in the relationship of polyunsaturated fatty acids and noninvasive imaging measures of subclinical cardiovascular disease.
Anderson, Jennifer S.

Sex differences in the relationship of polyunsaturated fatty acids and noninvasive imaging measures of subclinical cardiovascular disease. - 93 p.

Source: Masters Abstracts International, Volume: 49-06, page: .

Thesis (M.S.)--Wake Forest University, 2011.

Background. The association between plasma phospholipid omega-6 levels and cardiovascular disease (CVD) morbidity and mortality is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid (ALA).

ISBN: 9781124695099Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Sex differences in the relationship of polyunsaturated fatty acids and noninvasive imaging measures of subclinical cardiovascular disease.
LDR:03021nam 2200373 4500 001 1405627
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008 130515s2011 ||||||||||||||||| ||eng d
020 $a 9781124695099
035 $a (UMI)AAI1494542
035 $a AAI1494542
040 $a UMI $c UMI
100 1 $a Anderson, Jennifer S. $3 1685029
245 1 0 $a Sex differences in the relationship of polyunsaturated fatty acids and noninvasive imaging measures of subclinical cardiovascular disease.
300 $a 93 p.
500 $a Source: Masters Abstracts International, Volume: 49-06, page: .
500 $a Adviser: David M. Herrington.
502 $a Thesis (M.S.)--Wake Forest University, 2011.
520 $a Background. The association between plasma phospholipid omega-6 levels and cardiovascular disease (CVD) morbidity and mortality is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid (ALA).
520 $a Objective. To determine the associations between plasma phospholipid omega-6 (arachidonic acid (AA), linoleic acid (LA)) and omega-3 levels (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), ALA) with cardiac magnetic resonance imaging (CMR) measures of left ventricular and aortic dysfunction.
520 $a Design. Cross-sectional associations of plasma phospholipid levels with CMR measures of LV mass, LV volumes, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults from four racial/ethnic groups, aged 45--84 years, free of clinical CVD who underwent CMR at baseline examination.
520 $a Results. Results of multivariate analysis adjusted for age, race/ethnicity, gender, BMI, smoking, education, field center, physical activity, systolic blood pressure, total:HDL cholesterol, and total energy intake, showed no statistically significant associations of plasma phospholipid omega-6 or omega-3 levels with CMR measures at the a priori-specified level of p <0.01. However, in women, plasma phospholipid DHA was positively associated with LV mass (beta = 1.89, p = 0.02; p interaction = 0.003). Conversely, a trend for a positive association between plasma phospholipid DHA and ejection fraction was noted in men (beta = 0.009, p = 0.05; p interaction = 0.03).
520 $a Conclusions. Results suggest the association between plasma phospholipid DHA and CMR measures of LV mass and ejection fraction vary by gender. Additional research is warranted to clarify the effects of omega-3 fatty acids on cardiac structure and function in women versus men.
590 $a School code: 0248.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Health Sciences, Radiology. $3 1019076
690 $a 0570
690 $a 0574
710 2 $a Wake Forest University. $b Clinical and Population Translational Sciences. $3 1685030
773 0 $t Masters Abstracts International $g 49-06.
790 1 0 $a Herrington, David M., $e advisor
790 1 0 $a Vitolins, Mara $e committee member
790 1 0 $a Hundley, W. Gregory $e committee member
790 1 0 $a Morgan, Timothy $e committee member
790 1 0 $a Bell, Ronny $e committee member
790 $a 0248
791 $a M.S.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1494542