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Past, present, and future of sequenc...

Roskin, Krishna M.

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Past, present, and future of sequence alignment.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Past, present, and future of sequence alignment./
作者:	Roskin, Krishna M.
面頁冊數:	177 p.
附註:	Source: Dissertation Abstracts International, Volume: 72-06, Section: B, page: .
Contained By:	Dissertation Abstracts International72-06B.
標題:	Biology, Bioinformatics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3452516
ISBN:	9781124594941

Past, present, and future of sequence alignment.
Roskin, Krishna M.

Past, present, and future of sequence alignment. - 177 p.

Source: Dissertation Abstracts International, Volume: 72-06, Section: B, page: .

Thesis (Ph.D.)--University of California, Santa Cruz, 2011.

The aim of comparative genomics is to study variation between genomes to gain a deeper understanding of the forces and processes that shape them. In this dissertation, I chronicle my involvement at the dawn of mammalian comparative genomics when the second and third mammalian genome were sequenced and analyzed. This dissertation will cover the methods used to align the mouse and rat genomes to the human genome and how these methods enabled me to analyze the process of neutral evolution with unprecedented fidelity. This new wealth of data enabled the observation of large and fine scale variations in the processes of neutral evolution. My results and observations have impacted the field of comparative genomics and continue to be used in current literature. This dissertation also presents my work applying alignment algorithms to solve very large alignment problems. Continuing developments in alignment algorithms have produced more sophisticated and principled alignment methods. These new algorithms are often computationally expensive. I developed two general methods that harness the power of parallelization and enable these expensive methods to be applied to large, biologically relevant problems.

ISBN: 9781124594941Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Past, present, and future of sequence alignment.
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