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Optimization algorithms for biologic...

Dost, Banu.

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Optimization algorithms for biological data.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Optimization algorithms for biological data./
Author:	Dost, Banu.
Description:	173 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-04, Section: B, page: 2484.
Contained By:	Dissertation Abstracts International71-04B.
Subject:	Biology, Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3397170
ISBN:	9781109684223

Optimization algorithms for biological data.
Dost, Banu.

Optimization algorithms for biological data. - 173 p.

Source: Dissertation Abstracts International, Volume: 71-04, Section: B, page: 2484.

Thesis (Ph.D.)--University of California, San Diego, 2010.

High-throughput techniques in biology have enabled the generation of enormous amount of data allowing researchers to reveal systems level information deciphering the underlying dynamics and mechanisms of the cell. In the last few decades, the immense databases containing DNA, RNA and protein sequences, structures and abundance estimates have been available to researchers. Research in bioinformatics necessitates the use of advanced efficient algorithms to analyze and interpret those biological data. A common characteristic of high-throughput biological data is that it is often incomplete, noisy and inconsistent due to the biases and inefficiencies induced by the laboratory methods. That is why several of the problems defined on biological data can be viewed as constrained optimization problems.

ISBN: 9781109684223Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Optimization algorithms for biological data.
LDR:02506nam 2200337 4500 001 1395947
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020 $a 9781109684223
035 $a (UMI)AAI3397170
035 $a AAI3397170
040 $a UMI $c UMI
100 1 $a Dost, Banu. $3 1674689
245 1 0 $a Optimization algorithms for biological data.
300 $a 173 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-04, Section: B, page: 2484.
500 $a Adviser: Vineet Bafna.
502 $a Thesis (Ph.D.)--University of California, San Diego, 2010.
520 $a High-throughput techniques in biology have enabled the generation of enormous amount of data allowing researchers to reveal systems level information deciphering the underlying dynamics and mechanisms of the cell. In the last few decades, the immense databases containing DNA, RNA and protein sequences, structures and abundance estimates have been available to researchers. Research in bioinformatics necessitates the use of advanced efficient algorithms to analyze and interpret those biological data. A common characteristic of high-throughput biological data is that it is often incomplete, noisy and inconsistent due to the biases and inefficiencies induced by the laboratory methods. That is why several of the problems defined on biological data can be viewed as constrained optimization problems.
520 $a In this dissertation, I address different optimization problems that arise in the analysis of biological data: RNA structural alignment, protein interaction network querying, micro-array expression data clustering, protein quantification and protein modification site assignment. The dissertation begins with an overview of the basic concepts of molecular biology and an introduction to the optimization problems to be addressed. Then, each problem is discussed in detail in a separate chapter along with our contribution in the solution of the problem and our results on biological data opening a way for biological discoveries.
590 $a School code: 0033.
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Computer Science. $3 626642
690 $a 0715
690 $a 0984
710 2 $a University of California, San Diego. $b Computer Science and Engineering. $3 1018473
773 0 $t Dissertation Abstracts International $g 71-04B.
790 1 0 $a Bafna, Vineet, $e advisor
790 1 0 $a Pevzner, Pavel $e committee member
790 1 0 $a Ideker, Trey $e committee member
790 1 0 $a Briggs, Steve $e committee member
790 1 0 $a Saul, Lawrence $e committee member
790 $a 0033
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3397170