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Exploration of N-terminal methionine...

Bonissone, Stefano Romoli.

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Exploration of N-terminal methionine excision via comparative proteogenomics.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Exploration of N-terminal methionine excision via comparative proteogenomics./
Author:	Bonissone, Stefano Romoli.
Description:	60 p.
Notes:	Source: Masters Abstracts International, Volume: 48-04, page: 2311.
Contained By:	Masters Abstracts International48-04.
Subject:	Biology, Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1474117
ISBN:	9781109622768

Exploration of N-terminal methionine excision via comparative proteogenomics.
Bonissone, Stefano Romoli.

Exploration of N-terminal methionine excision via comparative proteogenomics. - 60 p.

Source: Masters Abstracts International, Volume: 48-04, page: 2311.

Thesis (M.S.)--University of California, San Diego, 2010.

This thesis will explore N-terminal methionine excision (NME), a co-translational process that occurs on virtually all proteins in all organimsms from bacteria to eukaryotes. NME is an essential process for the funtioning of proteins, with the enzymes responsible for carrying out NME belonging to the minimal bacterial cell [HPG+99]. This excision is almost exclusively determined by the second amino acid of the nascient protein. The set of seven amino acids that prompt cleavage also correspond to the seven stabilizing amino acids that Arfin and Bradshaw [AB88] connected to protein degradation. Comparative proteogenomics approaches are employed to perform an analysis of NME based on sequence as well as other available data. The ties of NME to protein degradation are questioned, with the results of experiments suggesting that only two of the seven amino acids that prompt cleavage are important and required for post-translational modifications, specifically N-acetylation.

ISBN: 9781109622768Subjects--Topical Terms:

1018415
Biology, Bioinformatics.

Exploration of N-terminal methionine excision via comparative proteogenomics.
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020 $a 9781109622768
035 $a (UMI)AAI1474117
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100 1 $a Bonissone, Stefano Romoli. $3 1669111
245 1 0 $a Exploration of N-terminal methionine excision via comparative proteogenomics.
300 $a 60 p.
500 $a Source: Masters Abstracts International, Volume: 48-04, page: 2311.
500 $a Adviser: Pavel Pevzner.
502 $a Thesis (M.S.)--University of California, San Diego, 2010.
520 $a This thesis will explore N-terminal methionine excision (NME), a co-translational process that occurs on virtually all proteins in all organimsms from bacteria to eukaryotes. NME is an essential process for the funtioning of proteins, with the enzymes responsible for carrying out NME belonging to the minimal bacterial cell [HPG+99]. This excision is almost exclusively determined by the second amino acid of the nascient protein. The set of seven amino acids that prompt cleavage also correspond to the seven stabilizing amino acids that Arfin and Bradshaw [AB88] connected to protein degradation. Comparative proteogenomics approaches are employed to perform an analysis of NME based on sequence as well as other available data. The ties of NME to protein degradation are questioned, with the results of experiments suggesting that only two of the seven amino acids that prompt cleavage are important and required for post-translational modifications, specifically N-acetylation.
590 $a School code: 0033.
650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Computer Science. $3 626642
690 $a 0715
690 $a 0984
710 2 $a University of California, San Diego. $b Computer Science and Engineering. $3 1018473
773 0 $t Masters Abstracts International $g 48-04.
790 1 0 $a Pevzner, Pavel, $e advisor
790 1 0 $a Bafna, Vineet $e committee member
790 1 0 $a Hoffmann, Alexander $e committee member
790 $a 0033
791 $a M.S.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1474117