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The role of extracellular matrix in ...

Gao, Yingxin.

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The role of extracellular matrix in lateral transmission of force in skeletal muscle.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The role of extracellular matrix in lateral transmission of force in skeletal muscle./
Author:	Gao, Yingxin.
Description:	178 p.
Notes:	Advisers: Alan S. Wineman; John A. Faulkner.
Contained By:	Dissertation Abstracts International68-02B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3253271

The role of extracellular matrix in lateral transmission of force in skeletal muscle.
Gao, Yingxin.

The role of extracellular matrix in lateral transmission of force in skeletal muscle. - 178 p.

Advisers: Alan S. Wineman; John A. Faulkner.

Thesis (Ph.D.)--University of Michigan, 2007.

This dissertation describes the role of extracellular matrix (ECM) in the lateral transmission of force. It consists of an experimental studies of the ECM and mathematical modeling of lateral transmission of force.Subjects--Topical Terms:

1017681
Biophysics, Medical.

The role of extracellular matrix in lateral transmission of force in skeletal muscle.
LDR:03070nam 2200337 a 45 001 972743
005 20110928
008 110928s2007 eng d
035 $a (UMI)AAI3253271
035 $a AAI3253271
040 $a UMI $c UMI
100 1 $a Gao, Yingxin. $3 1296716
245 1 4 $a The role of extracellular matrix in lateral transmission of force in skeletal muscle.
300 $a 178 p.
500 $a Advisers: Alan S. Wineman; John A. Faulkner.
500 $a Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 1250.
502 $a Thesis (Ph.D.)--University of Michigan, 2007.
520 $a This dissertation describes the role of extracellular matrix (ECM) in the lateral transmission of force. It consists of an experimental studies of the ECM and mathematical modeling of lateral transmission of force.
520 $a The effect of aging on the structural and mechanical properties of the epimysium of muscle of the rats were examined. No statistically significant differences were found in the ultrastructure, or the thickness of the epimysium. However, from the tensile stress-strain tests, it was found that the epimysium of muscles from old rats was much stiffer than that of the young rats. Based on these observations. It was concluded that the differences in the mechanical properties of the epimysium of the muscles from the old compared with young rats were not associated with the arrangement and size of collagen fibers in the epimysium. Consequently, other methods will be required to identify the structural bases of the mechanical differences.
520 $a The stress-strain relationships for the epimysiums of the skeletal muscles from both the young and old rats were found to be nonlinear. A mathematical model was developed that showed that the nonlinear behavior results from the waviness and the reorientation of the collagen fibers in the epimysium.
520 $a The ECM plays an important role in lateral transmission of force in skeletal muscle by providing shear stress between the muscle fibers or fascicles. A mathematical model was developed to investigate the mechanisms of lateral transmission. It was a modification of the shear lag theory for chopped fiber composite materials used in engineering applications. The modified shear lag theory includes an activation strain to account for muscle contraction and a myofibrils-endomysium interfaces that accounts for the molecular lateral linkages. The model was used to simulate the classic experiments of Street. It was demonstrated that lateral transmission of force in the skeletal muscle is affected by the mechanical and structural properties of the muscle fibers and its surrounding extracellular matrix.
590 $a School code: 0127.
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Materials Science. $3 1017759
650 4 $a Engineering, Mechanical. $3 783786
690 $a 0541
690 $a 0548
690 $a 0760
690 $a 0794
710 2 0 $a University of Michigan. $3 777416
773 0 $t Dissertation Abstracts International $g 68-02B.
790 $a 0127
790 1 0 $a Faulkner, John A., $e advisor
790 1 0 $a Wineman, Alan S., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3253271