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Neural correlates of the acquisition...

Honsberger, Michael J. M.

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Neural correlates of the acquisition of drug-cue associations.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Neural correlates of the acquisition of drug-cue associations./
作者:	Honsberger, Michael J. M.
面頁冊數:	47 p.
附註:	Source: Masters Abstracts International, Volume: 45-03, page: 1684.
Contained By:	Masters Abstracts International45-03.
標題:	Psychology, Psychobiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR23208
ISBN:	9780494232088

Neural correlates of the acquisition of drug-cue associations.
Honsberger, Michael J. M.

Neural correlates of the acquisition of drug-cue associations. - 47 p.

Source: Masters Abstracts International, Volume: 45-03, page: 1684.

Thesis (M.A.)--University of Guelph (Canada), 2006.

This thesis describes an investigation of the pattern of cellular activity displayed within the medial prefrontal cortex (mPFC), amygdala and the nucleus accumbens (Acb) during the acquisition of heroin (0.3 mg/kg SC) conditioned place preference. We measured Fos immunoreactivity (IR) in the target regions after the initial and final day of conditioning in four groups that received exposure to different aspects of condition; CS-US, CS only, US only, or noCS-noUS. After a single day of conditioning, neural activity was enhanced in the amygdala and mPFC by the administration of the drug. However, the response to heroin in the mPFC was enhanced by simultaneous exposure to the conditioning environment. In the Acb, there were equivalent increases in activity in all four groups. Importantly, group differences were only found after one day of conditioning, a conditioning period that a subsequent experiment demonstrated not to be sufficient to induce a significant place preference.

ISBN: 9780494232088Subjects--Topical Terms:

1017821
Psychology, Psychobiology.

Neural correlates of the acquisition of drug-cue associations.
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520 $a This thesis describes an investigation of the pattern of cellular activity displayed within the medial prefrontal cortex (mPFC), amygdala and the nucleus accumbens (Acb) during the acquisition of heroin (0.3 mg/kg SC) conditioned place preference. We measured Fos immunoreactivity (IR) in the target regions after the initial and final day of conditioning in four groups that received exposure to different aspects of condition; CS-US, CS only, US only, or noCS-noUS. After a single day of conditioning, neural activity was enhanced in the amygdala and mPFC by the administration of the drug. However, the response to heroin in the mPFC was enhanced by simultaneous exposure to the conditioning environment. In the Acb, there were equivalent increases in activity in all four groups. Importantly, group differences were only found after one day of conditioning, a conditioning period that a subsequent experiment demonstrated not to be sufficient to induce a significant place preference.
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