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Effects of repeated morphine depriva...

Cooper, Ziva D.

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Effects of repeated morphine deprivation on operant responding in rats.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Effects of repeated morphine deprivation on operant responding in rats./
作者:	Cooper, Ziva D.
面頁冊數:	144 p.
附註:	Adviser: James H. Woods.
Contained By:	Dissertation Abstracts International68-02B.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3253247

Effects of repeated morphine deprivation on operant responding in rats.
Cooper, Ziva D.

Effects of repeated morphine deprivation on operant responding in rats. - 144 p.

Adviser: James H. Woods.

Thesis (Ph.D.)--University of Michigan, 2007.

These studies determined the effects of repeated morphine deprivation on behavior maintained by various reinforcers in the rat. A morphine dosing schedule was designed and characterized to establish and maintain dependence while allowing for repeated observation of behavior during morphine deprivation-induced withdrawal. Self-administration of the mu-opioid agonist remifentanil was assessed in nondependent (morphine-naive) rats and compared with self-administration in morphine dependent and deprived groups. Morphine deprivation was found to enhance remifentanil self-administration. The selectivity of this effect was assessed by evaluating the effects of morphine deprivation on behavior maintained by cocaine and two food reinforcers. Deprivation did not alter cocaine self-administration; however, deprivation did enhance behavior maintained by both food reinforcers. The increase in food-maintained behavior observed in the deprived group was likely due to morphine induced food deprivation and consequent weight loss throughout the experiment. Finally, to further characterize morphine deprivation-induced changes on the reinforcing effectiveness of remifentanil, economic demand was determined in dependent and nondependent groups of rats. Compared with nondependent rats, morphine-deprived rats demonstrated less elastic demand for remifentanil indicating that deprivation increased its reinforcing effectiveness. These studies provide evidence that morphine dependence and deprivation enhances the reinforcing properties of remifentanil.Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Effects of repeated morphine deprivation on operant responding in rats.
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245 1 0 $a Effects of repeated morphine deprivation on operant responding in rats.
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500 $a Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 1355.
502 $a Thesis (Ph.D.)--University of Michigan, 2007.
520 $a These studies determined the effects of repeated morphine deprivation on behavior maintained by various reinforcers in the rat. A morphine dosing schedule was designed and characterized to establish and maintain dependence while allowing for repeated observation of behavior during morphine deprivation-induced withdrawal. Self-administration of the mu-opioid agonist remifentanil was assessed in nondependent (morphine-naive) rats and compared with self-administration in morphine dependent and deprived groups. Morphine deprivation was found to enhance remifentanil self-administration. The selectivity of this effect was assessed by evaluating the effects of morphine deprivation on behavior maintained by cocaine and two food reinforcers. Deprivation did not alter cocaine self-administration; however, deprivation did enhance behavior maintained by both food reinforcers. The increase in food-maintained behavior observed in the deprived group was likely due to morphine induced food deprivation and consequent weight loss throughout the experiment. Finally, to further characterize morphine deprivation-induced changes on the reinforcing effectiveness of remifentanil, economic demand was determined in dependent and nondependent groups of rats. Compared with nondependent rats, morphine-deprived rats demonstrated less elastic demand for remifentanil indicating that deprivation increased its reinforcing effectiveness. These studies provide evidence that morphine dependence and deprivation enhances the reinforcing properties of remifentanil.
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