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Neurophysiological effects of cocain...

Hollander, Jonathan Alan.

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Neurophysiological effects of cocaine abstinence.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Neurophysiological effects of cocaine abstinence./
作者:	Hollander, Jonathan Alan.
面頁冊數:	140 p.
附註:	Adviser: Regina M. Carelli.
Contained By:	Dissertation Abstracts International67-06B.
標題:	Psychology, Experimental. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3219089
ISBN:	9780542714979

Neurophysiological effects of cocaine abstinence.
Hollander, Jonathan Alan.

Neurophysiological effects of cocaine abstinence. - 140 p.

Adviser: Regina M. Carelli.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2006.

Cocaine addiction in humans is characterized by cycles of abstinence from drug-taking behavior and resumption of drug consumption (relapse). Numerous studies have implicated the brain 'reward' circuit, including the nucleus accumbens (Acb) and associated brain regions, in mediating drug-seeking behaviors. Using electrophysiological recording procedures in behaving rodents, we have shown that Acb neurons encode information about key aspects of goal-directed behaviors. Moreover, we have shown that cell firing in this region is sensitive to interruption (extinction) of response-reinforcement contingencies involving drug or natural rewards. To extend these findings to a more clinically relevant model, electrophysiological recording procedures were used here to determine the firing properties of Acb neurons following abstinence (i.e., experimenter-controlled removal of drug access) from cocaine self-administration.

ISBN: 9780542714979Subjects--Topical Terms:

517106
Psychology, Experimental.

Neurophysiological effects of cocaine abstinence.
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100 1 $a Hollander, Jonathan Alan. $3 1296436
245 1 0 $a Neurophysiological effects of cocaine abstinence.
300 $a 140 p.
500 $a Adviser: Regina M. Carelli.
500 $a Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3499.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2006.
520 $a Cocaine addiction in humans is characterized by cycles of abstinence from drug-taking behavior and resumption of drug consumption (relapse). Numerous studies have implicated the brain 'reward' circuit, including the nucleus accumbens (Acb) and associated brain regions, in mediating drug-seeking behaviors. Using electrophysiological recording procedures in behaving rodents, we have shown that Acb neurons encode information about key aspects of goal-directed behaviors. Moreover, we have shown that cell firing in this region is sensitive to interruption (extinction) of response-reinforcement contingencies involving drug or natural rewards. To extend these findings to a more clinically relevant model, electrophysiological recording procedures were used here to determine the firing properties of Acb neurons following abstinence (i.e., experimenter-controlled removal of drug access) from cocaine self-administration.
520 $a Experiments in Chapter 2 revealed that the percentage of Acb cells that encode cocaine-seeking behavior is dramatically increased during resumption of cocaine self-administration following 1-month cocaine abstinence. Extinction experiments in another set of rats revealed an increased motivational state for the drug following 1-month abstinence.
520 $a Studies in Chapter 3 showed that these effects were also observed in animals that underwent extended (2-month) abstinence from cocaine self-administration. Since there were possible confounding variables such as increased age and extended time of microwire implantation for the 2-month group, appropriate controls were included in this experiment.
520 $a The ability of cocaine-associated stimuli to elicit drug-seeking even after years of abstinence is problematic for addicts who wish to remain drug-free. In Chapter 4 we show that activation of Acb neurons by cocaine-associated stimuli was enhanced following 1-month cocaine abstinence regardless of contingency of cue presentation or cocaine availability.
520 $a Taken together, our results show that 1- and 2-month abstinence from cocaine self-administration causes a dramatic increase in the number and strength of Acb neurons that encode cocaine-related information (Chapters 2 & 3), and that Acb neurons are more responsive to cocaine-associated cues following 1-month abstinence across multiple environmental contexts (Chapter 4). Overall, the present report highlights cellular changes in the Acb following cocaine abstinence that may represent one type of neuroadapation related to cocaine taking and abstinence from drug use underlying the inability of cocaine addicts to remain drug free.
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650 4 $a Psychology, Physiological. $3 1017869
650 4 $a Psychology, Psychobiology. $3 1017821
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710 2 0 $a The University of North Carolina at Chapel Hill. $3 1017449
773 0 $t Dissertation Abstracts International $g 67-06B.
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