東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Serotonergic involvement in the beha...

Christianson, John Paul.

FindBook

Google Book

Amazon

博客來

Serotonergic involvement in the behavioral depression produced by intermittent swim stress.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Serotonergic involvement in the behavioral depression produced by intermittent swim stress./
作者:	Christianson, John Paul.
面頁冊數:	103 p.
附註:	Adviser: Robert C. Drugan.
Contained By:	Dissertation Abstracts International67-05B.
標題:	Psychology, Behavioral. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3217422
ISBN:	9780542685774

Serotonergic involvement in the behavioral depression produced by intermittent swim stress.
Christianson, John Paul.

Serotonergic involvement in the behavioral depression produced by intermittent swim stress. - 103 p.

Adviser: Robert C. Drugan.

Thesis (Ph.D.)--University of New Hampshire, 2006.

Exposure to uncontrollable stress produces a behavioral syndrome that is often described as "behavioral depression" in the rat. Current paradigms for inducing behavioral depression utilize continuous swimming or intermittent electric shock stress. Brown et al., developed a novel strategy that combined these stressors to produce the intermittent swim stress (ISS) protocol. The purpose of this thesis was to define the behavioral outcomes of ISS that resemble behavioral depression and to begin neurochemical characterization of the phenomenon.

ISBN: 9780542685774Subjects--Topical Terms:

1017677
Psychology, Behavioral.

Serotonergic involvement in the behavioral depression produced by intermittent swim stress.
LDR:03507nam 2200301 a 45 001 972421
005 20110927
008 110927s2006 eng d
020 $a 9780542685774
035 $a (UMI)AAI3217422
035 $a AAI3217422
040 $a UMI $c UMI
100 1 $a Christianson, John Paul. $3 1296428
245 1 0 $a Serotonergic involvement in the behavioral depression produced by intermittent swim stress.
300 $a 103 p.
500 $a Adviser: Robert C. Drugan.
500 $a Source: Dissertation Abstracts International, Volume: 67-05, Section: B, page: 2870.
502 $a Thesis (Ph.D.)--University of New Hampshire, 2006.
520 $a Exposure to uncontrollable stress produces a behavioral syndrome that is often described as "behavioral depression" in the rat. Current paradigms for inducing behavioral depression utilize continuous swimming or intermittent electric shock stress. Brown et al., developed a novel strategy that combined these stressors to produce the intermittent swim stress (ISS) protocol. The purpose of this thesis was to define the behavioral outcomes of ISS that resemble behavioral depression and to begin neurochemical characterization of the phenomenon.
520 $a Two hallmark features of behavioral depression are immobility, as determined in a Forced Swim Test (FST) and escape learning deficits, as determined by operant tasks such as the shuttlebox test. In Experiment 1, rats were exposed to either ISS or confinement and, 24 hours later, subjected to a swim escape test (SET) designed to analogue the shuttlebox test in a swim context. Prior stress interfered with escape acquisition in the SET.
520 $a The results of previous studies suggest that stress causes a temporary activation of the brain serotonin (5-HT) system that is necessary and sufficient for producing behavioral depression. If this hypothesis is true in the ISS paradigm, then enhancing or inhibiting 5-HT transmission during stress should exacerbate or block the development of behavioral depression, respectively. In Experiment 2 the selective 5-HT uptake inhibitor, fluoxetine, was administered prior to ISS or confinement, 24 h later the FST was used to detect behavioral immobility. ISS, but not fluoxetine, significantly increased immobility in the FST. In Experiment 3, the 5-HT uptake enhancer, tianeptine, was administered in place of fluoxetine. Again ISS increased immobility in the FST, but tianeptine had no effect. These results suggested that 5-HT is not a critical mediator of ISS induced behavioral depression. However, some authors have raised concern that tianeptine does not act directly on 5-HT and, therefore, the results of Experiment 3 are difficult to interpret. Experiment 4 utilized the 5-HT synthesis inhibitor, para-chlorophenylaline (PCPA) to deplete 5-HT before stress. PCPA did not alter immobility in the FST. Taken together, these experiments indicate that ISS produces a significant behavioral depression manifested as increased immobility and poor escape learning. Furthermore, the current data do not support the hypothesis that the 5-HT system is a critical substrate of intermittent swim stress. Results are discussed within a framework of the neurobiology of uncontrollable stressors.
590 $a School code: 0141.
650 4 $a Psychology, Behavioral. $3 1017677
650 4 $a Psychology, Psychobiology. $3 1017821
690 $a 0349
690 $a 0384
710 2 0 $a University of New Hampshire. $3 1017788
773 0 $t Dissertation Abstracts International $g 67-05B.
790 $a 0141
790 1 0 $a Drugan, Robert C., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3217422