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The role of protein kinase A and CRE...

Tronson, Natalie Celia.

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The role of protein kinase A and CREB in bidirectional behavioral plasticity of memory after retrieval.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The role of protein kinase A and CREB in bidirectional behavioral plasticity of memory after retrieval./
作者:	Tronson, Natalie Celia.
面頁冊數:	234 p.
附註:	Adviser: Jane R. Taylor.
Contained By:	Dissertation Abstracts International67-04B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3214316
ISBN:	9780542658075

The role of protein kinase A and CREB in bidirectional behavioral plasticity of memory after retrieval.
Tronson, Natalie Celia.

The role of protein kinase A and CREB in bidirectional behavioral plasticity of memory after retrieval. - 234 p.

Adviser: Jane R. Taylor.

Thesis (Ph.D.)--Yale University, 2006.

Reconsolidation has been defined an active process that stabilizes memory after retrieval, and is hypothesized to be a critical component of memory processing. Disruption of reconsolidation after memory retrieval results in impairments of that memory at a subsequent test. This finding has allowed the initial determination of molecular mechanisms of reconsolidation---if inhibition of a protein after retrieval impairs memory at a later test, then that protein is said to be required for memory reconsolidation. Reconsolidation theory, however, is controversial and opponents have suggested that disruptions of reconsolidation are temporary impairments of retrieval processes.

ISBN: 9780542658075Subjects--Topical Terms:

1017680
Biology, Neuroscience.

The role of protein kinase A and CREB in bidirectional behavioral plasticity of memory after retrieval.
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100 1 $a Tronson, Natalie Celia. $3 1296421
245 1 4 $a The role of protein kinase A and CREB in bidirectional behavioral plasticity of memory after retrieval.
300 $a 234 p.
500 $a Adviser: Jane R. Taylor.
500 $a Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 2273.
502 $a Thesis (Ph.D.)--Yale University, 2006.
520 $a Reconsolidation has been defined an active process that stabilizes memory after retrieval, and is hypothesized to be a critical component of memory processing. Disruption of reconsolidation after memory retrieval results in impairments of that memory at a subsequent test. This finding has allowed the initial determination of molecular mechanisms of reconsolidation---if inhibition of a protein after retrieval impairs memory at a later test, then that protein is said to be required for memory reconsolidation. Reconsolidation theory, however, is controversial and opponents have suggested that disruptions of reconsolidation are temporary impairments of retrieval processes.
520 $a This dissertation attempts to examine the psychological nature of, and molecular basis for reconsolidation by testing the hypothesis that reconsolidation can be enhanced, thereby strengthening memory. If reconsolidation is a mechanism that stores and maintains memories, then like consolidation, bidirectional modulation of one protein or signaling pathway should result in bidirectional modulation of reconsolidation. The experiments focused on the cyclic-AMP/protein kinase A (PKA) cascade, and its downstream target, the transcription factor cAMP response element binding protein (CREB), within the basolateral amygdala. Because PKA and CREB are also modulated by acute and chronic drugs of abuse, we also tested the hypothesis that post-retrieval amphetamine would enhance reconsolidation of an auditory fear memory.
520 $a Disruption of either PKA or CREB in the basolateral amygdala after retrieval of an auditory fear memory resulted in decreased freezing at a later test. Activation of PKA in the basolateral amygdala or systemic administration of amphetamine after retrieval increased freezing at subsequent drug-free tests, demonstrating that reconsolidation can be enhanced. These effects were independent of changes to extinction of fear.
520 $a The bidirectional modification of memory after retrieval provides strong evidence for reconsolidation as a consolidation-like storage and maintenance mechanism. The enhancements of reconsolidation also suggest that reconsolidation may play an important role in the long-term maintenance of old memories.
520 $a It has previously been speculated that post-retrieval manipulations may provide an important time-point for therapeutic intervention in psychiatric disorders such as post-traumatic stress disorder and drug addiction, in which intractable memories play a central role. The demonstration that reconsolidation can be enhanced implies that aberrant reconsolidation may also contribute to the development and maintenance of these disorders.
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650 4 $a Psychology, Cognitive. $3 1017810
650 4 $a Psychology, Psychobiology. $3 1017821
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710 2 0 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 67-04B.
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