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The role of semaphorin3D in the deve...

Sakai, Jill A.

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The role of semaphorin3D in the development of the zebrafish optic chiasm.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The role of semaphorin3D in the development of the zebrafish optic chiasm./
作者:	Sakai, Jill A.
面頁冊數:	154 p.
附註:	Adviser: Mary C. Halloran.
Contained By:	Dissertation Abstracts International67-12B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3245636

The role of semaphorin3D in the development of the zebrafish optic chiasm.
Sakai, Jill A.

The role of semaphorin3D in the development of the zebrafish optic chiasm. - 154 p.

Adviser: Mary C. Halloran.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2006.

During nervous system development, axons navigate to their synaptic targets directed by a series of molecular guidance cues. The retinotectal pathway is composed of axons of retinal ganglion cells (RGCs), which project from the eye to the optic tectum and transmit visual information to the brain. RGC axons leave the eye and grow toward the midline of the ventral diencephalon, where the axon bundles from opposite eyes cross to form the X-shaped optic chiasm. At the midline, axons can cross to the opposite side of the brain or turn back to innervate the ipsilateral side, a decision that is important for achieving correct representation of the visual field in the brain. Although the majority of RGC axons project contralaterally, the guidance decision to cross the midline is not well understood. Sema3D, a secreted member of the semaphorin family of guidance cues, is expressed at the midline of the zebrafish ventral diencephalon where the chiasm forms. In this thesis, I show that Sema3D guides RGC axons as they form the optic chiasm. In Chapter 2, I present evidence that Sema3D promotes midline crossing and formation of the contralateral pathway. In Chapter 3, I show that Sema3D may guide axons by mediating axon fasciculation. In Chapter 4, I discuss roles of adhesion molecules in RGC axon guidance. This work identifies Sema3D as an important regulator of RGC midline crossing during development of the visual system.Subjects--Topical Terms:

1017680
Biology, Neuroscience.

The role of semaphorin3D in the development of the zebrafish optic chiasm.
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245 1 4 $a The role of semaphorin3D in the development of the zebrafish optic chiasm.
300 $a 154 p.
500 $a Adviser: Mary C. Halloran.
500 $a Source: Dissertation Abstracts International, Volume: 67-12, Section: B, page: 6921.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2006.
520 $a During nervous system development, axons navigate to their synaptic targets directed by a series of molecular guidance cues. The retinotectal pathway is composed of axons of retinal ganglion cells (RGCs), which project from the eye to the optic tectum and transmit visual information to the brain. RGC axons leave the eye and grow toward the midline of the ventral diencephalon, where the axon bundles from opposite eyes cross to form the X-shaped optic chiasm. At the midline, axons can cross to the opposite side of the brain or turn back to innervate the ipsilateral side, a decision that is important for achieving correct representation of the visual field in the brain. Although the majority of RGC axons project contralaterally, the guidance decision to cross the midline is not well understood. Sema3D, a secreted member of the semaphorin family of guidance cues, is expressed at the midline of the zebrafish ventral diencephalon where the chiasm forms. In this thesis, I show that Sema3D guides RGC axons as they form the optic chiasm. In Chapter 2, I present evidence that Sema3D promotes midline crossing and formation of the contralateral pathway. In Chapter 3, I show that Sema3D may guide axons by mediating axon fasciculation. In Chapter 4, I discuss roles of adhesion molecules in RGC axon guidance. This work identifies Sema3D as an important regulator of RGC midline crossing during development of the visual system.
590 $a School code: 0262.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Zoology. $3 1018632
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