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The effects of deep brain stimulatio...

Ciucci, Michelle Renee.

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The effects of deep brain stimulation on deglutition in Parkinson disease.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The effects of deep brain stimulation on deglutition in Parkinson disease./
作者:	Ciucci, Michelle Renee.
面頁冊數:	117 p.
附註:	Adviser: Julie M. Barkmeier-Kraemer.
Contained By:	Dissertation Abstracts International67-04B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3215655
ISBN:	9780542649370

The effects of deep brain stimulation on deglutition in Parkinson disease.
Ciucci, Michelle Renee.

The effects of deep brain stimulation on deglutition in Parkinson disease. - 117 p.

Adviser: Julie M. Barkmeier-Kraemer.

Thesis (Ph.D.)--The University of Arizona, 2006.

Relatively little is known about the role of the basal ganglia and their pathways in human deglutition. Deep Brain Stimulation (DBS) is a treatment for Parkinson Disease (PD) that stimulates the subthalamic nuclei and affords us a model for examining deglutition in humans with known impairment of the basal ganglia. The purpose of this study was to examine the effects of DBS in the ON versus Off conditions on the oral and pharyngeal stages of deglutition in participants with PD. It was hypothesized that DBS in the ON condition would yield improvement in the following dependent variables: oral total composite score, pharyngeal total composite score, pharyngeal transit time, and maximal hyoid bone excursion. Statistically significant differences (improvement) were found for the pharyngeal composite score and pharyngeal transit time in the DBS ON condition. Findings of this study demonstrated that DBS in the ON condition helps to alleviate some of the bradykinesia and hypokinesia associated with PD on the pharyngeal stage of deglutition, but not the oral stage. These findings suggest that Parkinsonian swallowing dysfunction is not solely related to nigrostriatal dopamine deficiency which is purported to be the primary means of DBS alleviation of motor signs. Rather, it may be due to an additional non-dopamine related system of deglutition found in the brainstem.

ISBN: 9780542649370Subjects--Topical Terms:

1017680
Biology, Neuroscience.

The effects of deep brain stimulation on deglutition in Parkinson disease.
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