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The acute effects of differential di...

Bradley, Nicolette Shannon.

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The acute effects of differential dietary fatty acids on PDHa activity in human skeletal muscle at the onset of exercise.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The acute effects of differential dietary fatty acids on PDHa activity in human skeletal muscle at the onset of exercise./
作者:	Bradley, Nicolette Shannon.
面頁冊數:	101 p.
附註:	Source: Masters Abstracts International, Volume: 45-01, page: 0304.
Contained By:	Masters Abstracts International45-01.
標題:	Biology, Cell. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR17986
ISBN:	9780494179864

The acute effects of differential dietary fatty acids on PDHa activity in human skeletal muscle at the onset of exercise.
Bradley, Nicolette Shannon.

The acute effects of differential dietary fatty acids on PDHa activity in human skeletal muscle at the onset of exercise. - 101 p.

Source: Masters Abstracts International, Volume: 45-01, page: 0304.

Thesis (M.Sc.)--Brock University (Canada), 2006.

Pyruvate dehydrogenase (PDH) is an important regulator of carbohydrate oxidation during exercise and its activity can be down-regulated by an increase in dietary fat. The purpose of this study was to determine the acute metabolic effects of differential dietary fatty acids on the activation of PDH in its active form (PDHa) at rest and at the onset of moderate-intensity exercise. University-aged male subjects (n=7) underwent 2 fat loading trials spaced at least 2 weeks apart. Subjects consumed saturated (SFA) or polyunsaturated (PUFA) fat over the course of 5 hours. Following this, participants cycled at 65% VO2 max for 15 min. Muscle biopsies were taken prior to and following fat loading and at 1 min exercise. Plasma free fatty acids increased from 0.15+/-0.07 to 0.54+/-0.19 mM over 5 hours with SFA and from 0.11+/-0.04 to 0.350.13 mM with PUFA. PDHa activity was unchanged following fat loading, but increased at the onset of exercise in the SFA trial, from 1.4+/-0.4 to 2.2+/-0.4 mumol/min/kg wet wt. This effect was negated in the PUFA trial (1.2+/-0.3 to 1.3+/-0.3 mumol/min/kg wet wt.). PDH kinase (PDK) was unchanged in both trials, suggesting that the attenuation of PDHa activity with PUFA was a result of changes in the concentrations of intramitochondrial effectors, more specifically intramitochondrial NADH or Ca2+. Our findings suggest that attenuated PDHa activity participates in the preferential oxidation of PUFA during moderate-intensity exercise.

ISBN: 9780494179864Subjects--Topical Terms:

1017686
Biology, Cell.

The acute effects of differential dietary fatty acids on PDHa activity in human skeletal muscle at the onset of exercise.
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