東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

The influence of insulin-like growth...

Hand, Brian Dudley.

Linked to FindBook

Google Book

Amazon

博客來

The influence of insulin-like growth factor pathway gene polymorphisms on the strength training response of muscle phenotypes in older adults.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The influence of insulin-like growth factor pathway gene polymorphisms on the strength training response of muscle phenotypes in older adults./
Author:	Hand, Brian Dudley.
Description:	287 p.
Notes:	Adviser: Ben F. Hurley.
Contained By:	Dissertation Abstracts International67-11B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3241509
ISBN:	9780542962172

The influence of insulin-like growth factor pathway gene polymorphisms on the strength training response of muscle phenotypes in older adults.
Hand, Brian Dudley.

The influence of insulin-like growth factor pathway gene polymorphisms on the strength training response of muscle phenotypes in older adults. - 287 p.

Adviser: Ben F. Hurley.

Thesis (Ph.D.)--University of Maryland, College Park, 2006.

Strength training (ST) is considered an intervention of choice for the prevention and treatment of the adverse consequences of sarcopenia. Our group previously reported that the CA dinucleotide repeat polymorphism in the promoter region of the insulin-like growth factor 1 (IGF1) gene influenced the muscle strength response to ST in Caucasians. Other studies have shown that the insulin-like growth factor binding protein-3 (IGFBP-3) is a modulator of IGF-1 in circulation and is present in skeletal muscle. The -202 polymorphism in the promoter region of the IGFBP3 gene has been shown to influence IGFBP-3 levels. In addition, there have been reports that IGF-1 and calcineurin are linked in a common pathway to induce skeletal muscle cell hypertrophy. A previous study has shown that an insertion/deletion (I/D) polymorphism in the gene encoding the regulatory subunit of calcineurin, calcineurin B, influences cardiac hypertrophy. To examine the influence of these IGF pathway gene polymorphisms on muscle mass and strength responses to ST, we studied 128 Caucasian and African American men and women before and after a 10-wk single-leg knee extension ST program. One repetition maximum strength (1 RM), muscle volume (MV), and muscle quality (MQ) were assessed at baseline and after 10 wk of ST.

ISBN: 9780542962172Subjects--Topical Terms:

1017730
Biology, Genetics.

The influence of insulin-like growth factor pathway gene polymorphisms on the strength training response of muscle phenotypes in older adults.
LDR:03396nam 2200301 a 45 001 969190
005 20110920
008 110921s2006 eng d
020 $a 9780542962172
035 $a (UMI)AAI3241509
035 $a AAI3241509
040 $a UMI $c UMI
100 1 $a Hand, Brian Dudley. $3 1293244
245 1 4 $a The influence of insulin-like growth factor pathway gene polymorphisms on the strength training response of muscle phenotypes in older adults.
300 $a 287 p.
500 $a Adviser: Ben F. Hurley.
500 $a Source: Dissertation Abstracts International, Volume: 67-11, Section: B, page: 6173.
502 $a Thesis (Ph.D.)--University of Maryland, College Park, 2006.
520 $a Strength training (ST) is considered an intervention of choice for the prevention and treatment of the adverse consequences of sarcopenia. Our group previously reported that the CA dinucleotide repeat polymorphism in the promoter region of the insulin-like growth factor 1 (IGF1) gene influenced the muscle strength response to ST in Caucasians. Other studies have shown that the insulin-like growth factor binding protein-3 (IGFBP-3) is a modulator of IGF-1 in circulation and is present in skeletal muscle. The -202 polymorphism in the promoter region of the IGFBP3 gene has been shown to influence IGFBP-3 levels. In addition, there have been reports that IGF-1 and calcineurin are linked in a common pathway to induce skeletal muscle cell hypertrophy. A previous study has shown that an insertion/deletion (I/D) polymorphism in the gene encoding the regulatory subunit of calcineurin, calcineurin B, influences cardiac hypertrophy. To examine the influence of these IGF pathway gene polymorphisms on muscle mass and strength responses to ST, we studied 128 Caucasian and African American men and women before and after a 10-wk single-leg knee extension ST program. One repetition maximum strength (1 RM), muscle volume (MV), and muscle quality (MQ) were assessed at baseline and after 10 wk of ST.
520 $a There was a significant combined gene effect, including both IGF1 main effect and IGF1 by calcineurin B ( PPP3R1) gene by gene interaction effect, for change in strength with ST (P < 0.01). There was also a significant combined gene effect for IGF1 on change in MQ (P < 0.05). The gene by gene interaction of IGF1 and PPP3R1 by itself, approached significance for change in strength with ST (P = 0.07) and was right on the border of significance for change in MQ (P = 0.05). Moreover, PPP3R1 II homozygotes approached significance for a greater increase in MV with ST than PPP3R1 D-allele carriers (P = 0.06). There were no significant combined gene effect for PPP3R1 (i.e., PPP3R1 main effect combined with PPP3R1 by IGF1 interaction effect) for change in strength or MQ with ST. Also, there were no significant influences of the IGFBP3 polymorphism on muscle phenotypic responses to ST. These data extend our previous findings for IGF1 by indicating that IGF pathway gene polymorphisms may influence muscle phenotypic responses to ST in Caucasian and African American older men and women.
590 $a School code: 0117.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Physiology. $3 1017816
650 4 $a Health Sciences, Recreation. $3 1018003
690 $a 0369
690 $a 0575
690 $a 0719
710 2 0 $a University of Maryland, College Park. $3 657686
773 0 $t Dissertation Abstracts International $g 67-11B.
790 $a 0117
790 1 0 $a Hurley, Ben F., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3241509