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Physiological and pathological tremo...

Sturman, Molly M.

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Physiological and pathological tremor: Effects of deep brain stimulation and medication.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Physiological and pathological tremor: Effects of deep brain stimulation and medication./
作者:	Sturman, Molly M.
面頁冊數:	151 p.
附註:	Adviser: Daniel M. Corcos.
Contained By:	Dissertation Abstracts International67-09B.
標題:	Health Sciences, Medicine and Surgery. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3233219
ISBN:	9780542873089

Physiological and pathological tremor: Effects of deep brain stimulation and medication.
Sturman, Molly M.

Physiological and pathological tremor: Effects of deep brain stimulation and medication. - 151 p.

Adviser: Daniel M. Corcos.

Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2006.

The aim of this dissertation was to investigate the neurophysiological characteristics of physiological and pathological tremor with the intent of (1) examining how the neurophysiological characteristics of physiological tremor change with age, (2) establishing potential candidate biomarkers to distinguish healthy physiological tremor across a wide spectrum of ages from disease, and (3) determining the efficacy of deep brain stimulation (DBS) and medication for the treatment of parkinsonian tremor. The first study examined the neurophysiological characteristics of resting and postural physiological tremor in healthy adults aged 20-94 years. Forty healthy subjects were divided into four age groups. Data from ten patients with PD and six patients with ET were also presented. Tremor was examined at rest and during postural maintenance of the limb under both loaded and unloaded conditions. Results showed that postural tremor regularity and postural tremor-EMG coherence in the 1-8 Hz frequency bin were significantly increased in the oldest subjects. Despite this increase there was a clear demarcation between physiological tremor in the elderly and pathological tremor. The second and third studies examined the effects of DBS and antiparkinsonian medication on the neurophysiological characteristics of resting and postural tremor under quiet conditions (second study), and during a motor and a cognitive secondary task (third study). Tremor in these two studies was quantified in exactly the same manner as the first study. Ten patients with PD who received DBS and ten healthy age matched control subjects were enrolled in each study. DBS reduced tremor amplitude, regularity, and tremor-EMG coherence, and increased tremor frequency during the quiet and cognitive tasks. However, the motor task was able to reduce tremor amplitude to the same extent as DBS. DBS was better able to alter the neurophysiological characteristics of resting and postural tremor in PD compared with medication across three task conditions. The findings from these studies are discussed in relation to the current models of tremor circuitry for both physiological and pathological tremors. Additionally, the different mechanisms of action that DBS may have on the central oscillator(s) of parkinsonian tremor, and the differential effects of DBS and antiparkinsonian medication are addressed.

ISBN: 9780542873089Subjects--Topical Terms:

1017756
Health Sciences, Medicine and Surgery.

Physiological and pathological tremor: Effects of deep brain stimulation and medication.
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